The effects of running activity on the reproductive axes of rodents.
The effects of running activity on the reproductive axes of rodents.
复制标题
跑步活动对啮齿动物生殖轴的影响。
DOI：
10.1007/bf00192723
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Bronson,FH
中科院分区：
文献类型：
--
作者：
Kerbeshian,MC;LePhuoc,H;Bronson,FH
叙利亚仓鼠的生殖轴因昼长较短而受到抑制，接近转轮会导致它们的性腺复发（Borer et al. 1983）。第一个实验测试了这种现象在啮齿类动物种群中的普遍性，这些啮齿类动物的生殖光反应性基因不同。两种极端表型的雄性草地田鼠（Microtus pennsylvanicus）——生殖光反应型和非光反应型——要么被提供跑步轮，要么不提供跑步轮。4周后，应答田鼠的生殖功能完全恢复，而无应答田鼠的生殖轴仍然受到抑制。三个实验询问使用轮子是否会对其他啮齿动物产生生殖刺激作用。首先，与没有轮子的老鼠相比，有轮子的完整雄性老鼠的睾丸大小没有增加。同样，对于睾丸因植入睾酮而部分退化的雄性大鼠，或者通过将雌性小鼠分组饲养而抑制其发情周期的雌性小鼠，运动活动也没有影响。因此，运动活动增强促性腺激素分泌的神经内分泌途径与光周期控制GnRH分泌的途径特异性相关。
Access to a running wheel causes gonadal recrudescence in Syrian hamsters whose reproductive axes have been suppressed by housing them under short day lengths (Borer et al. 1983). The first experiment tested the generality of this phenomenon in a population of rodents that is genetically heterogeneous for reproductive photoresponsiveness. Male meadow voles (Microtus pennsylvanicus) of the two extreme phenotypes — reproductively photoresponsive and non-responsive — were either provided with a running wheel or housed without one. After 4 weeks with a wheel, the responsive voles had recovered full reproductive function, while the reproductive axes of responsive voles housed without wheels remained suppressed. Three experiments queried whether the use of a wheel would have reproductively stimulative effects in other rodents. First, intact male mice given access to wheels showed no increase in testis size when compared to mice housed without wheels. Likewise, locomotor activity had no effect on male rats whose testes were partially regressed in response to testosterone implants or on female mice whose estrous cycles were pheromonally suppressed by housing them in groups. Thus the neuroendocrine pathway used by locomotor activity to enhance the secretion of gonadotropin is specifically allied with the pathway used by photoperiod to control GnRH secretion.