MicroRNAs and Lipoprotein Metabolism.
MicroRNAs and Lipoprotein Metabolism.
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DOI：
10.5551/jat.20859
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发表时间：
2014-01
影响因子：
4.4
通讯作者：
Takahiro Horie;Osamu Baba;Y. Kuwabara;M. Yokode;T. Kita;Takeshi Kimura;K. Ono
中科院分区：
文献类型：
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作者：
Takahiro Horie;Osamu Baba;Y. Kuwabara;M. Yokode;T. Kita;Takeshi Kimura;K. Ono
microRNAs（miRNAs; miRs）是一类非蛋白质编码的小分子RNA，对基因表达起负调控作用。它们与特定的mRNA结合并抑制翻译或促进mRNA降解。最近，一些miRNAs已被证明参与脂质稳态。特别地，miR 122和miR-33对脂质稳态具有显著影响，并且是用于治疗脂质病症和/或动脉粥样硬化的潜在治疗靶标。在这篇综述中，我们描述了目前的理解的功能的miRNA在脂质稳态，重点是脂蛋白代谢。
MicroRNAs(miRNAs; miRs) are small, non-protein-coding RNAs that negatively regulate the gene expression. They bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recently, some miRNAs have been shown to be involved in lipid homoeostasis. In particular, miR122 and miR-33 have a significant impact on lipid homeostasis and are potential therapeutic targets for treating lipid disorders and/or atherosclerosis. In this review, we describe the current understanding of the function of miRNAs in lipid homeostasis, with a focus on lipoprotein metabolism.