Infection with Chlamydia trachomatis lymphogranuloma venereum serovar L1 in homosexual men with proctitis: molecular analysis of an unusual case cluster.
Infection with Chlamydia trachomatis lymphogranuloma venereum serovar L1 in homosexual men with proctitis: molecular analysis of an unusual case cluster.
复制标题
患有直肠炎的同性恋男性沙眼衣原体淋巴肉芽肿血清型 L1 感染：异常病例群的分子分析。
DOI：
10.1093/clinids/20.3.576
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Stamm,WE
中科院分区：
文献类型：
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作者：
Bauwens,JE;Lampe,MF;Suchland,RJ;Wong,K;Stamm,WE
Among 767 rectal isolates ofChlamydia trachomatisobtained from men over the period 1981–1991, 7 were found to be a rare lymphogranuloma venereum serovar, L1. These isolates were from rectal specimens taken from five male patients in 1982–1983. Six of the seven isolates were available for DNA sequencing studies. All six of these isolates shared the same DNA sequence in the major outer membrane protein (MOMP) gene variable domains and had different MOMP sequences than did the prototype L1, L2, and L3 strains, suggesting a point source outbreak. All five patients infected with serovar L-1 were homosexual men who had symptomatic proctitis characterized by rectal pain, discharge, tenesmus, abnormalities seen on anoscopy, and leukocytes seen on gram stains of rectal specimens. We conclude that an unrecognized point source outbreak of the rare chlamydial L1 serovar occurred among homosexual men in Seattle in 1982–1983, and that the clinical manifestations of L1 infection may be less severe than those of L2 infections.
