Osteoporosis and renal dysfunction in a general population exposed to cadmium in China
Osteoporosis and renal dysfunction in a general population exposed to cadmium in China
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DOI：
10.1016/j.envres.2004.02.012
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发表时间：
2004-11-01
影响因子：
8.3
通讯作者：
Bernard, A
中科院分区：
文献类型：
--
作者：
Jin, TY;Nordberg, G;Bernard, A
骨质疏松症是一种常见的代谢性疾病，其特征是骨量减少和骨组织微结构的破坏。骨质疏松症的发生与多种因素有关。镉可引起骨软化症和骨质疏松症，这些影响早已通过各种流行病学或实验研究进行了调查。本研究探讨了镉肾病与其对中国东南部污染地区人群骨骼的影响之间的可能关系。采用单光子吸收法测量人群的骨密度，并引入Z评分（个体骨密度测量值与性别和年龄匹配对照组平均值之差的SD数）来定义骨质疏松症（Z评分< -2）。本研究在中国环境接触镉的一般人群中证实了镉暴露引起的骨质疏松症。结果表明，不同尿镉组间骨质疏松患病率差异有显著性（χ 2 = 18.84，P = 0.0008）。线性趋势检验得出卡方（2）= 16.281，P = 0.00005。镉暴露（尿镉）与骨质疏松患病率之间存在剂量-反应关系。在31例骨质疏松症受试者中，23例受试者患有肾功能不全。肾功能不全的患病率（74.19%）明显高于无骨质疏松组（χ 2 = 16.53，P
Osteoporosis is a common metabolic disease characterized by low bone mass and microarchitectural deterioration of bone tissue. Many factors are involved in the occurrence of osteoporosis. Cadmium can cause both osteomalacia and osteoporosis and these effects have long been investigated through various epidemiological or experimental studies. The present study examines a possible relationship between cadmium nephropathy and its effects on the skeleton in populations living in a polluted area in southeast China. Monophoton absorptiometry was used to measure bone mineral density in the population and the Z score (the number of SD from the difference between the measured bone density of the individual and the group mean value for sex- and age-matched controls) was introduced to define osteoporosis (Z score < -2). Osteoporosis caused by cadmium exposure was demonstrated in this study on a general population environmentally exposed to cadmium in China. It was found that there were significant differences in the prevalence of osteoporosis among the different urinary cadmium groups chi(2) = 18.84, P = 0.0008). The linear trend test gave chi(2) = 16.281, P = 0.00005. There was a dose-response relationship between cadmium exposure (urinary cadmium) and prevalence of osteoporosis. Of 31 subjects with osteoporosis, 23 subjects were suffering from renal dysfunction. The prevalence of renal dysfunction (74.19%) was significantly higher than that in those without osteoporosis (chi(2) = 16.53, P