Effects of development on acetoacetyl-CoA synthetase biosynthesis in rat liver.
Effects of development on acetoacetyl-CoA synthetase biosynthesis in rat liver.
复制标题
发育对大鼠肝脏乙酰乙酰辅酶A合成酶生物合成的影响。
DOI：
10.1248/bpb.22.981
复制
发表时间：
1999
影响因子：
2
通讯作者：
T. Fukui
中科院分区：
文献类型：
--
作者：
M. Nakamoto;N. Takahashi;A. Iwahori;H. Sato;T. Fukui
为了研究胞质内乙酰乙酸酯激活酶乙酰乙酰辅酶a合成酶（acetoacetate-CoA ligase, EC 6.2.1.16）的生理作用，在大鼠肝脏中研究了动物发育对该酶活性和含量的影响。雄性大鼠的酶比活性在4周龄较2周龄增加21倍后逐渐降低，雌性大鼠的酶比活性在6周龄时与雄性大鼠相似，但随后又进一步增加，达到最大值，约为雄性大鼠的3倍。酶含量的发育模式与酶比活性的发育模式相关。这些结果表明，在发育过程中该酶的活性和含量的变化可能会影响大鼠肝脏对酮体形成生理上重要的脂质物质的利用率。
In order to investigate the physiological role of acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, EC 6.2.1.16), a cytosolic acetoacetate-activating enzyme, the effects of animal development on the activity and content of the enzyme were examined in rat liver. In male rats, the enzyme specific activity increased 21-fold at 4 weeks of age from that at 2 weeks of age, and then gradually decreased, while in female rats, it increased similarly to that of male rats, but further increased, reaching a maximum about 3-fold higher than that of male rats, at 6 weeks of age. The developmental patterns of the enzyme content correlated with that of the enzyme specific activity. These results indicate that changes in this enzyme activity and content during the developmental process might influence the rate of ketone body utilization for the formation of physiologically important lipidic substances in rat liver.