Changes in testicular weight and serum gonadotropin and testosterone levels before, during, and after birth in the perinatal rat.
Changes in testicular weight and serum gonadotropin and testosterone levels before, during, and after birth in the perinatal rat.
复制标题
围产期大鼠出生前、出生期间和出生后睾丸重量以及血清促性腺激素和睾酮水平的变化。
作者：
P. Corbier;B. Kerdelhué;R. Picon;J. Roffi
在新生雄性大鼠出生前、出生期间和出生后 24 小时内测量了血清和垂体 LH 和 FSH 浓度的变化。出生时观察到血清和垂体促性腺激素突然短暂增加，随后 2--12 小时内绝对和相对睾丸重量快速增加（P 小于 0.0001），并且在子宫内 0 小时（810 +/- 26 pg/ml）和 2 小时（2820 +/- 318 pg/ml；P 小于0.0001）。同样，妊娠第20天剖腹产的早产新生大鼠也表现出睾丸重量在0--6小时之间增加，血清睾酮水平在0小时（730+/-170pg/ml）和2小时（3400+/-300pg/ml；P小于0.001）之间增加，而血清LH仅略有增加。这些结果表明，大鼠的垂体睾丸轴在出生时受到刺激。讨论了造成这种刺激的因素。出生时发生的短暂睾丸危象可能会影响大鼠中枢神经系统的雄性化过程。
Changes in serum and pituitary LH and FSH concentrations have been measured in the newborn male rat before, during, and up to 24 h after birth. A sudden and transient increase of serum and pituitary gonadotropins is observed at birth, which is followed by a rapid increase of absolute and relative testicular weights between 2--12 h (P less than 0.0001) and by a transient increase of serum testosterone between 0 h in utero (810 +/- 26 pg/ml) and 2 h (2820 +/- 318 pg/ml; P less than 0.0001). Similarly, premature newborn rats obtained by cesarian delivery on day 20 of gestation also exhibited an increase in testicular weight between 0--6 h and an increase in serum testosterone levels between 0 h (730 +/- 170 pg/ml) and 2 h (3400 +/- 300 pg/ml; P less than 0.001) with only a slight increase in serum LH. These results show that the hypophyseo-testicular axis of the rats is stimulated at the moment of birth. The factors responsible for this stimulation are discussed. This transient testicular crisis occurring at birth could affect the process of masculinization of the central nervous system of the rat.