Relationship between follicle-stimulating hormone, androstenedione and oestradiol in human follicular fluid.
Relationship between follicle-stimulating hormone, androstenedione and oestradiol in human follicular fluid.
复制标题
人卵泡液中促卵泡激素、雄烯二酮和雌二醇之间的关系。
DOI：
10.1677/joe.0.0760527
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
D. Baird
中科院分区：
文献类型：
--
作者：
K. McNatty;D. Baird
在月经周期的不同阶段，测定了正常和囊性卵泡卵泡液中FSH、雌二醇和雄烯二酮的浓度。此外，还测定了卵泡中颗粒细胞的数量。在卵泡中，FSH是可检测的，雌二醇的浓度大于雄烯二酮，无论阶段的周期。与此相反，在那些卵泡中，FSH是不可检测的，在所有的囊性卵泡无论FSH的水平，雄烯二酮的浓度大于雌二醇。在含有FSH的卵泡中，颗粒细胞数与卵泡雌二醇浓度呈极显著线性相关（P <0.001）。提示在人卵巢中，卵泡液中高达90%的雌二醇可能来源于颗粒细胞。
The concentrations of FSH, oestradiol and androstenedione in the follicular fluid of normal and cystic human follicles were measured at different stages of the menstrual cycle. In addition, the number of granulosa cells in the follicles was determined. In follicles in which FSH was detectable, the concentration of oestradiol was greater than that of androstenedione, irrespective of the stage of the cycle. In contrast, in those follicles in which FSH was undetectable and in all cystic follicles irrespective of the level of FSH, the concentration of androstenedione was greater than that of oestradiol. In follicles containing FSH there was a highly significant linear correlation between the number of granulosa cells and the concentration of follicular oestradiol (P less than 0.001). It is suggested that in human ovaries up to 90% of the oestradiol in follicular fluid may originate from the granulosa cells.