Acetylcholine release in hippocampus and striatum during testing on a rewarded spontaneous alternation task.
Acetylcholine release in hippocampus and striatum during testing on a rewarded spontaneous alternation task.
复制标题
在奖励自发交替任务测试期间海马和纹状体中乙酰胆碱的释放。
DOI：
10.1016/j.nlm.2005.05.001
复制
发表时间：
2005
影响因子：
2.7
通讯作者：
Gold,PaulE
中科院分区：
文献类型：
--
作者：
Pych,JasonC;Chang,Qing;Colon-Rivera,Cynthia;Gold,PaulE
The present experiment tested male Sprague–Dawley rats for spontaneous alternation performance in a food-rewarded Y-shaped maze. Microdialysis samples, later assessed for acetylcholine concentration, were collected from the hippocampus and striatum of each rat prior to and during testing; testing sessions lasted 20min. Early in testing, rats alternated at a rate of 72%. Alternation scores increased throughout the 20-min testing session and reached 93% during the last 5min. The behavioral findings suggest that, during testing, rats changed the basis for their performance from a spatial working memory strategy to a persistent turning strategy. ACh release in both hippocampus and striatum increased at the onset of testing. Increases in ACh release in the striatum began at 18% above baseline during the first 5min of testing and steadily increased reaching 58% above baseline during the final 5min. The progressive rise of striatum ACh release during testing occurred at about the time rats adopted a persistent turning strategy. In contrast, ACh release in the hippocampus increased by 50% with the onset of testing and remained at this level until declining slightly during the last 5min of testing. The relative changes in ACh release in the striatum and hippocampus resulted in a close negative relationship between the ratio of ACh release in the hippocampus/striatum and alternation scores.
