Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii maxim
Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii maxim
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DOI：
10.1021/ol062748d
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发表时间：
2007-01-18
期刊：
影响因子：
5.2
通讯作者：
Zhao, Qin-Shi
中科院分区：
文献类型：
--
作者：
Xu, Gang;Hou, Ai-Jun;Zhao, Qin-Shi
[图]Przewalskin B (1) 是一种具有独特骨架的新型二萜类化合物，是从中药植物鼠尾草中分离得到的。通过广泛的 NMR 分析和单晶 X 射线研究阐明了其结构和相关立体化学。提出了 1 的可能生物合成途径。化合物1表现出适度的抗HIV-1活性，EC50=30μg/mL。
[GRAPHIC]Przewalskin B (1), a novel diterpenoid possessing a unique skeleton, was isolated from a Chinese medicinal plant Salvia przewalskii. Its structure and relative stereochemistry were elucidated by extensive NMR analysis and a single-crystal X-ray study. A possible biosynthetic pathway for 1 was proposed. Compound 1 exhibited modest anti-HIV-1 activity with EC50 = 30 mu g/mL.