Multicomponent mathematical model for tumor volume calculation with setup error using single-isocenter stereotactic radiotherapy for multiple brain metastases
Multicomponent mathematical model for tumor volume calculation with setup error using single-isocenter stereotactic radiotherapy for multiple brain metastases
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DOI：
10.1007/s13246-023-01241-8
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发表时间：
2023-03
影响因子：
4.4
通讯作者：
Hisashi Nakano;T. Shiinoki;S. Tanabe;Toshimichi Nakano;T. Takizawa;S. Utsunomiya;Madoka Sakai;Shunpei Tanabe;Atsushi Ohta;M. Kaidu;T. Nishio;Hiroyuki Ishikawa
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作者：
Hisashi Nakano;T. Shiinoki;S. Tanabe;Toshimichi Nakano;T. Takizawa;S. Utsunomiya;Madoka Sakai;Shunpei Tanabe;Atsushi Ohta;M. Kaidu;T. Nishio;Hiroyuki Ishikawa
我们评估了肿瘤残留体积，考虑到立体定向放射治疗（SRT）中的六个自由度（6DoF）患者摆位误差，使用单等中心照射脑转移瘤的多组分数学模型。使用直径为1.0（GTV 1）、2.0（GTV 2）和3.0（GTV 3）cm的模拟球形大体肿瘤体积（GTV）。GTV中心与等中心之间的距离（d）设定为0-10 cm。利用仿射变换，GTV同时在0-1.0 mm（T）内平移并在0°-1.0°（R）内旋转三个轴向。我们使用非小细胞肺癌细胞系（A549和NCI-H460）生长的测量来优化肿瘤生长模型参数。当GTV尺寸、d和6DoF设置误差变化时，我们使用对GTV的物理剂量来计算照射结束时的GTV剩余体积。确定了满足基于辐照前GTV体积的GTV残留体积率公差值（10%、35%和50%）的d值。为两条单元线设置的公差值越大，满足公差值的距离就越长。在基于多组分数学模型的单等中心照射SRT GTV残余体积评估中，GTV尺寸越小，距离和6DoF设置误差越大，满足公差值的距离可能需要越短。
We evaluated the tumor residual volumes considering six degrees-of-freedom (6DoF) patient setup errors in stereotactic radiotherapy (SRT) with multicomponent mathematical model using single-isocenter irradiation for brain metastases. Simulated spherical gross tumor volumes (GTVs) with 1.0 (GTV 1), 2.0 (GTV 2), and 3.0 (GTV 3)-cm diameters were used. The distance between the GTV center and isocenter (d) was set at 0–10 cm. The GTV was simultaneously translated within 0–1.0 mm (T) and rotated within 0°–1.0° (R) in the three axis directions using affine transformation. We optimized the tumor growth model parameters using measurements of non-small cell lung cancer cell lines’ (A549 and NCI-H460) growth. We calculated the GTV residual volume at the irradiation’s end using the physical dose to the GTV when the GTV size,d, and 6DoF setup error varied. Thed-values that satisfy tolerance values (10%, 35%, and 50%) of the GTV residual volume rate based on the pre-irradiation GTV volume were determined. The larger the tolerance value set for both cell lines, the longer the distance to satisfy the tolerance value. In GTV residual volume evaluations based on the multicomponent mathematical model on SRT with single-isocenter irradiation, the smaller the GTV size and the larger the distance and 6DoF setup error, the shorter the distance that satisfies the tolerance value might need to be.