Thiamine supplementation increases serum thiamine and reduces pyruvate and lactate levels in burn patients
Thiamine supplementation increases serum thiamine and reduces pyruvate and lactate levels in burn patients
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DOI：
10.1016/j.burns.2009.04.012
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发表时间：
2010-03-01
期刊：
影响因子：
2.7
通讯作者：
Fear, Mark W.
中科院分区：
文献类型：
--
作者：
Falder, Sian;Silla, Robyn;Fear, Mark W.
维生素对于最佳新陈代谢的重要性是众所周知的。然而，目前对于烧伤患者所需的最佳维生素水平知之甚少。因此，当前不同烧伤单位补充大量营养素和补充维生素的做法差异很大。更好地了解维生素对代谢的影响可能会带来更好的营养，从而改善烧伤患者的预后。硫胺素是参与碳水化合物代谢的多种酶所需的重要辅助因子。我们检查了烧伤患者的硫胺素 (B1) 水平，以及补充硫胺素对血清硫胺素、丙酮酸盐和乳酸水平的影响。 20 名患者在入院当天、入院后第 1、3、7 天以及此后每周采集血样直至出院。其中九人接受肠内喂养。六名患者接受了硫胺素补充剂。在每个时间点测量血清硫胺素、丙酮酸盐和乳酸水平。补充硫胺素后，血清硫胺素水平显着增加（p
The importance of vitamins for optimal metabolism is well established. However, currently little is known about the optimal vitamin levels required for burn patients. As a consequence, current practice both for macronutrient supplementation and vitamin supplementation varies widely between burn units. A better understanding of the effects of vitamins on metabolism may lead to better nutrition and subsequently improved outcomes for burn patients.Thiamine is an important co-factor required for multiple enzymes involved in carbohydrate metabolism. We have examined the levels of thiamine (B1) in burn patients as well as the effects of thiamine supplementation on the levels of serum thiamine, pyruvate and lactate.Twenty patients had blood samples taken on the day of admission, then on days 1, 3, and 7 post-admission and weekly thereafter until discharge. Of these, nine received enteral feeding. Six patients received thiamine supplementation. Serum thiamine, pyruvate and lactate levels were measured at each time point.Serum thiamine levels increased significantly with thiamine supplementation (p