High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines
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DOI：
10.1111/1469-0691.12422
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发表时间：
2014-07-01
影响因子：
14.2
通讯作者：
Munoz-Almagro, C.
中科院分区：
文献类型：
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作者：
del Amo, E.;Brotons, P.;Munoz-Almagro, C.
七价肺炎球菌结合疫苗PCV 7的实施导致携带和致病的肺炎球菌种群发生了重大变化。我们的目的是确定西班牙加泰罗尼亚结合疫苗时代导致侵袭性儿科疾病的血清型的侵袭性疾病潜力，以及13价肺炎球菌结合疫苗PCV 13的潜在覆盖率。作为次要目的，我们评估了PCV 7的实施是否导致该地区最常见血清型的侵袭性疾病潜力发生显著变化。比较了2007年至2011年期间从Sant Joan de Deu大学医院（西班牙巴塞罗那）住院儿童中获得的两种肺炎球菌收集物：第一组159种侵袭性疾病分离株，第二组209种鼻咽分离株从因小手术住院的健康儿童中回收。最常见的侵袭性血清型为1型（24.5%，n = 39）、19 A型（21.2%，n = 34）、5型（8.8%，n = 14）、7 F型（8.8%，n = 14）和3型（5%，n = 8）。最常见的血清型为19A（10%，n = 21）、6C（9%，n = 19）、23B（8.1%，n = 17）、6A（7.6%，n = 16）和19F（6.2%，n = 13）。观察到血清型1、3、5、7F和19A引起侵袭性疾病的倾向显著更高，所有这些都包括在PCV 13中。经过错误发现率校正后，血清型1、5、7 F和19 A的结果具有稳健性。非PCV13血清型具有较低的侵袭性疾病潜力。我们的数据加强了持续监测的必要性，并应鼓励在我们地区的儿童中普及PCV 13疫苗接种。
The implementation of the seven-valent pneumococcal conjugate vaccine, PCV7, has resulted in significant changes in the pneumococcal population being carried and causing disease. We aimed to determine the invasive disease potential of serotypes causing invasive paediatric disease in the era of conjugate vaccines in Catalonia, Spain, and their potential coverage by the 13-valent pneumococcal conjugate vaccine, PCV13. As a secondary objective, we evaluated whether implementation of PCV7 had resulted in significant changes in the invasive disease potential of the most frequent serotypes circulating in the area. Two pneumococcal collections obtained from children admitted to the University Hospital Sant Joan de Deu (Barcelona, Spain) between 2007 and 2011 were compared: a first set of 159 invasive disease isolates, and a second set of 209 nasopharyngeal isolates recovered from healthy children admitted for minor surgery. The most common invasive serotypes were 1 (24.5%, n = 39), 19A (21.2%, n = 34), 5 (8.8%, n = 14), 7F (8.8%, n = 14) and 3 (5%, n = 8). The most common serotypes in carriage were 19A (10%, n = 21), 6C (9%, n = 19), 23B (8.1%, n = 17), 6A (7.6%, n = 16) and 19F (6.2%, n = 13). A significantly higher propensity to cause invasive disease was observed for serotypes 1, 3, 5, 7F and 19A, all of which are included in PCV13. After false-discovery-rate correction, the results were robust for serotypes 1, 5, 7F and 19A. Non-PCV13 serotypes had a low invasive disease potential. Our data reinforce the need for continuous surveillance and should encourage efforts to introduce universal vaccination with PCV13 in children in our region.