Quantification of penile fat infiltration using the mDIXON Quant sequence: a pilot study on the correlation with penis hardness and erectile dysfunction
Quantification of penile fat infiltration using the mDIXON Quant sequence: a pilot study on the correlation with penis hardness and erectile dysfunction
复制标题
使用 mDIXON Quant 序列量化阴茎脂肪浸润：与阴茎硬度和勃起功能障碍相关性的初步研究
DOI：
10.1259/bjr.20201400
复制
发表时间：
2021-01-01
影响因子：
2.6
通讯作者：
Guo, Ruo-Mi
中科院分区：
文献类型：
--
作者：
Yang, Fei;Li, Qing-Ling;Guo, Ruo-Mi
目的：应用mDIXON Quant序列测定阴茎脂肪/水信号比值，定量评价阴茎脂肪浸润情况，探讨其与阴茎硬度和勃起功能障碍的关系。方法：对62例患者进行常规盆腔MRI检查，其中正常组22例，勃起硬度正常组20例，勃起功能障碍组20例。用mDIXON Quant序列测量阴茎中脂肪/水的信号比率。结果：海绵体的脂肪/水信号比在正常组(p=0.03)和勃起功能障碍组(p<；0.01)明显低于阴茎海绵体(p=0.03)。正常勃起硬化组与正常勃起硬化组的脂肪/水信号比值差异无统计学意义。正常勃起硬度组的阴茎脂肪浸润率明显低于勃起硬化组，而勃起硬度明显高于勃起硬化组，左右阴茎海绵体脂肪浸润率与阴茎勃起硬度呈负相关。结论：mDIXON Quant可作为一种无创性、定量、客观的方法评价阴茎脂肪浸润率。这种方法可以帮助诊断勃起功能障碍和不同体重指数患者的阴茎脂肪渗透。我们的结果还可以通过定量测量阴茎脂肪渗透来更准确地诊断和监测勃起硬度功能。知识进展：(1)质子密度脂肪分数技术是客观、定量和非侵入性评价阴茎脂肪渗透的新工具。(2)阴茎海绵体脂肪渗入的定量测量有助于更准确地诊断和监测阴茎勃起硬度及其功能。
Objective: The purpose of this study was to determine fat/water signal ratios using the mDIXON Quant sequence, quantitatively assess fat infiltration in the penis, and explore its possible relationship with penile hardness and erectile dysfunction.Methods: Routine pelvic MRI with the mDIXON Quant sequence was performed in 62 subjects, including 22 people in the normal group, 20 people in the normal erectile hardness group, and 20 people in the erectile dysfunction (ED) group. The fat/water signal ratio in the penis was measured using the mDIXON Quant sequence. Shear wave elastography was used to evaluate the hardness of the corpus cavernosa of the penis.Results: The fat/water signal ratio of the corpus spongiosum was significantly lower than that of the corpus cavernosa in the normal group (p = 0.03) and ED group (p < 0.01). There was no significant difference in the fat/ water signal ratios between the normal group and the normal erectile hardness group. Fat infiltration was significantly lower, and erectile hardness was significantly higher in the normal erectile hardness group than in the ED group, and the fat infiltration in the left and right corpus cavernosa was inversely proportional to the erectile hardness of the penis.Conclusion: This study suggests that mDIXON Quant can be used as a non-invasive, quantitative, and objective method for evaluating penile fat infiltration. This method could help diagnose penile fat infiltration in patients with erectile dysfunction and varying body mass indexes. Our results could also allow for a more accurate diagnosis and monitoring of erectile hardness function by quantitatively measuring penile fat infiltration.Advances in knowledge: (1) The proton density fat fraction technology is a new tool for the objective, quantitative and non-invasive evaluation of penile fat infiltration. (2) The quantitative measurement of fat infiltration in the corpora cavernosa might help diagnose and monitor penile erection hardness and its function more accurately.