PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations
PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations
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DOI：
10.1212/01.wnl.0000142258.29304.fe
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发表时间：
2004-10-26
期刊：
影响因子：
9.9
通讯作者：
Hattori, N
中科院分区：
文献类型：
--
作者：
Hatano, Y;Sato, K;Hattori, N
作者对39个parkin和DJ-1突变阴性的常染色体隐性早发性PD（AR-EOPD）家系进行了连锁分析。包括3个日本人、2个台湾人、1个土耳其人、1个以色列人和1个菲律宾人在内的8个家庭在D1 S2732显示了与PARK 6连锁的证据，多点对数比值（lod）得分为9.88。结果表明PARK 6相关帕金森综合征的全球分布。
The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.