AP1 transcription factors in epidermal differentiation and skin cancer.
AP1 transcription factors in epidermal differentiation and skin cancer.
复制标题
DOI：
10.1155/2013/537028
复制
发表时间：
2013
影响因子：
1.1
通讯作者：
Rorke EA
中科院分区：
文献类型：
--
作者：
Eckert RL;Adhikary G;Young CA;Jans R;Crish JF;Xu W;Rorke EA
AP1 （jun/fos）转录因子（c-jun、junB、junD、c-fos、FosB、Fra-1和Fra-2）是表皮角质形成细胞存活和分化的关键调控因子，也是癌症发展的重要驱动因素。了解这些因子在表皮中的作用是复杂的，因为在表皮分化过程中，每种蛋白在多个细胞层中以不同的水平表达，而且AP1转录因子调节竞争过程（即增殖、凋亡和分化）。各种体内遗传方法已被用于研究这些蛋白，包括表皮中显性阴性灭活AP1转录因子的靶向和条件敲除、过表达和表达。综上所述，这些研究表明，单个AP1转录因子在表皮和癌症发展中具有不同的功能，改变AP1转录因子在基底层和上基底层的功能对表皮分化反应和疾病和癌症的发展有不同的影响。
AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in epidermis is complicated by the fact that each protein is expressed, at different levels, in multiple cells layers in differentiating epidermis, and because AP1 transcription factors regulate competing processes (i.e., proliferation, apoptosis, and differentiation). Various in vivo genetic approaches have been used to study these proteins including targeted and conditional knockdown, overexpression, and expression of dominant-negative inactivating AP1 transcription factors in epidermis. Taken together, these studies suggest that individual AP1 transcription factors have different functions in the epidermis and in cancer development and that altering AP1 transcription factor function in the basal versus suprabasal layers differentially influences the epidermal differentiation response and disease and cancer development.