The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non-small cell lung cancer
The preoperative platelet distribution width: A predictive factor of the prognosis in patients with non-small cell lung cancer
复制标题
术前血小板分布宽度：非小细胞肺癌患者预后的预测因素
DOI：
10.1111/1759-7714.13340
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发表时间：
2020-02-15
期刊：
影响因子：
2.9
通讯作者：
Wang, Changli
中科院分区：
文献类型：
--
作者：
Liu, Chang;Zhang, Hua;Wang, Changli
背景血小板分布宽度（PDW）对不同恶性肿瘤的预后价值不同。本研究的目的是确定术前PDW与非小细胞肺癌（NSCLC）患者生存的关系。方法采用受试者工作特征（ROC）曲线确定PDW的最佳截止值。采用Kaplan-Meier法和log-rank检验估计无病生存期（DFS）和总生存期（OS）。单因素和多因素考克斯回归模型用于预后分析。采用似然比检验（LRT）和Akaike信息准则（AIC）比较两种TNM分期模型和PDW TNM分期模型（PDW与TNM分期的组合）的差异。结果生存分析显示，PDW > 12.65的患者的无病生存期（DFS）和总生存期（OS）均显著长于PDW
Background The prognostic value of platelet distribution width (PDW) is different in various malignancies. The purpose of this study was to identify the relationship between preoperative PDW and survival in patients with non-small cell lung cancer (NSCLC).Methods Optimal cutoff values of PDW were confirmed using a receiver operating characteristic (ROC) curve. The Kaplan-Meier method and log-rank test were used to estimate disease-free survival (DFS) and overall survival (OS). Univariate and multivariate Cox regression models were used for prognostic analysis. The likelihood ratio test (LRT) and Akaike information criterion (AIC) were used to compare two models of the TNM staging system and the PDW-TNM staging system (combination of PDW and the TNM staging system).Results Survival analysis indicated that the disease-free survival (DFS) and overall survival (OS) of patients with PDW > 12.65 were both significantly longer than those of patients with PDW