EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PC10), P53 PROTEIN AND C-ERBB-2 IN RENAL ADENOCARCINOMA
EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PC10), P53 PROTEIN AND C-ERBB-2 IN RENAL ADENOCARCINOMA
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DOI：
10.1002/ijc.2910570224
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发表时间：
1994-04-15
影响因子：
6.4
通讯作者：
SYRJANEN, K
中科院分区：
文献类型：
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作者：
LIPPONEN, P;ESKELINEN, M;SYRJANEN, K
应用免疫组化方法检测了123例有随访资料的肾腺癌中增殖细胞核抗原（PC 10）、p53蛋白（CMI）和c-erbB-2（NCL-1）的表达。c-erbB-2蛋白在10%的肿瘤中呈弱灶性表达，其表达与临床或组织学变量或生存率无关。p53蛋白在33%的肿瘤中表达。p53蛋白表达与肿瘤的分期、分级及预后无关，而c-erbB-2与p53蛋白表达之间相关性较弱。所有肿瘤均表达增殖细胞核抗原，且PC 10阳性细胞核比例与分级、分期和预后显着相关。对临床、组织学和免疫组化预后因素的多因素分析表明，肿瘤的范围、组织学分化程度和癌细胞增殖率是最重要的预后因素。无复发生存期与PC 10阳性细胞核比例、组织分化、性别和p53蛋白表达有关。p53蛋白过表达与长期无复发生存期有关。我们的研究结果表明，PC 10免疫标记可用于确定肾腺癌的预后类别，而p53蛋白或c-erbB-2的表达只是弱的预后指标。(C)1994 Wiley-Liss，Inc.
Expressions of proliferating cell nuclear antigen (PC10), p53 protein (CMI) and c-erbB-2 (NCL-I) were immunohistochemically analysed in 123 renal adenocarcinomas with known follow-up data. c-erbB-2 protein was weakly and focally expressed in 10% of the tumours, and the expression was not related to clinical or histological variables or survival. p53 protein as expressed in 33% of the tumours. Expression of p53 protein was independent of stage, grade and prognosis, while expressions of c-erbB-2 and p53 were weakly interrelated. Proliferating cell nuclear antigen was expressed in all tumours, and the fraction of PC10-positive nuclei was significantly related to grade, stage and prognosis. Multivariate analysis of clinical, histological and immunohistochemical prognostic factors indicated that the extent of the tumour, its histological differentiation and proliferation rate of the cancer cells are the most important prognostic factors. Recurrence-free survival was related to the fraction of PC10-positive nuclei, histological differentiation, sex and expression of p53 protein. Overexpression of p53 protein was related to a long recurrence-free survival. Our results show that PC10 immunolabelling can be used to determine the prognostic category in renal adenocarcinoma, whereas the expressions of p53 protein or c-erbB-2 are only weak prognostic indicators. (C) 1994 Wiley-Liss, Inc.