Nausea and Vomiting During Pregnancy is Highly Heritable
Nausea and Vomiting During Pregnancy is Highly Heritable
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DOI：
10.1007/s10519-016-9781-7
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发表时间：
2016-07-01
影响因子：
2.6
通讯作者：
Medland, Sarah E.
中科院分区：
文献类型：
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作者：
Colodro-Conde, Lucia;Jern, Patrick;Medland, Sarah E.
怀孕期间恶心和呕吐（NVP）影响了大约70%的孕妇，通常会影响她们的身体健康和心理社会功能。本研究的目的是估计NVP的存在、持续时间和严重程度的遗传度。样本由1723名女性（M（年龄）= 41.78，SD = 11.67）组成，包括完全和不完全配对的双胞胎及其来自NVP遗传学联盟两个队列的姐妹篇。样本包括159个同卵和140个异卵完全双胞胎对，和69个双胞胎姐妹对。我们使用OpenMx和Mx进行扩展孪生设计进行二次分析。NVP的个体差异最好用加性遗传和独特的环境效应来解释。NVP存在的遗传度估计值为73%（95%CI = 57- 84%），持续时间为51%（95%CI = 36- 63%），严重程度为53%（95%CI = 38- 65%）。病程与病情严重程度之间的遗传相关性几乎是完美的。我们的研究结果表明，基因在NVP的不同方面发挥着重要作用，并证明了寻找遗传变异的重要性。
Nausea and vomiting during pregnancy (NVP) affects about 70 % of all expectant mothers and commonly impacts their physical health and psychosocial functioning. The aim of this study was to estimate the heritability of the presence, duration and severity of NVP. The sample consisted of 1723 women (M (age) = 41.78, SD = 11.67) including twins in both complete and incomplete pairs and their sisters from two cohorts participating in the NVP Genetics Consortium. The sample comprised 159 monozygotic and 140 dizygotic complete twin pairs, and 69 twin-sister pairs. We applied an extended twin design using OpenMx and Mx for secondary analysis. Individual differences in NVP were best explained by additive genetic and unique environmental effects. Heritability estimates were 73 % (95 % CIs = 57-84 %) for presence, 51 % (95 % CIs = 36-63 %) for duration and 53 % (95 % CIs = 38-65 %) for severity of NVP. The genetic correlation between duration and severity was almost perfect. Our results show that genes play an important role in different aspects of NVP and justify the importance of searching for genetic variants.