EXCESSIVE MINERALIZATION WITH GROWTH PLATE CLOSURE IN RATS ON CHRONIC WARFARIN TREATMENT
EXCESSIVE MINERALIZATION WITH GROWTH PLATE CLOSURE IN RATS ON CHRONIC WARFARIN TREATMENT
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DOI：
10.1073/pnas.79.24.7734
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
JEE, WSS
中科院分区：
文献类型：
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作者：
PRICE, PA;WILLIAMSON, MK;JEE, WSS
维持8个月的华法林水平足以使骨中维生素k依赖性蛋白（骨玻璃蛋白）降低到正常水平的2%，大鼠会出现过度矿化障碍，其特征是胫骨近端生长板完全融合和纵向生长停止。这种异常的一般特征类似于人类胎儿华法林综合征，也是一种以生长板过度矿化为特征的疾病。这些过度矿化障碍可能是由骨玻璃蛋白水平下降引起的，骨玻璃蛋白是一种在体外有效抑制矿化的蛋白质。
Rats maintained for 8 mo. on a level of warfarin sufficient to decrease the vitamin K-dependent protein of bone (bone Gla protein) to 2% of normal have an excessive mineralization disorder characterized by complete fusion of the proximal tibial growth plate and cessation of longitudinal growth. The general features of this abnormality resemble the fetal warfarin syndrome in humans, a disorder also characterized by excessive mineralization of the growth plate. These excessive mineralization disorders may be caused by the decreased levels of bone Gla protein, a protein that potently inhibits mineralization in vitro.