Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
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DOI：
10.1038/nn1432
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发表时间：
2005-08-01
影响因子：
25
通讯作者：
Huganir, R
中科院分区：
文献类型：
--
作者：
Kim, CH;Takamiya, K;Huganir, R
AMPA受体GluR1亚基的c端PDZ配体可能对CA1海马长期增强的表达有重要作用。为了在体内直接测试这一点，我们制造了一只缺失GluR1最后七个残基的敲入小鼠，这些残基包括PDZ配体。这种缺失不影响基底GluR1突触定位、基底突触传递、长期增强或长期抑制，表明该配体不是CA1海马突触可塑性所必需的。
The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.