Perinatal stem cells: A promising cell resource for tissue engineering of craniofacial bone.
Perinatal stem cells: A promising cell resource for tissue engineering of craniofacial bone.
复制标题
DOI：
10.4252/wjsc.v7.i1.149
复制
发表时间：
2015-01
影响因子：
4.1
通讯作者：
Jiawen Si;Xu-Dong Wang;S. G. Shen
中科院分区：
文献类型：
--
作者：
Jiawen Si;Xu-Dong Wang;S. G. Shen
在面对日益增加的临床挑战和次优技术的颅面骨缺损所造成的各种条件，如先天性畸形，骨髓炎，创伤和肿瘤切除，正在进行的研究再生医学使用干细胞和同步的进步，在生物技术已经转移的重点从外科重建到一个新的干细胞为基础的组织工程策略定制和功能性颅面骨再生。鉴于围产期干细胞独特的个体遗传学和细胞生物学特性，新出现的证据表明这些胚外组织来源的干细胞是再生医学和组织工程中广泛使用的有前途的细胞来源。本文综述了近年来干细胞诱导颅面骨再生的研究进展和存在的问题，并对不同类型的围产期干细胞的特性及其在颅面骨组织工程中的应用进行了综述。我们提出了有前途的可行性和围产期干细胞为基础的颅面骨组织工程的范围为未来的临床应用。
In facing the mounting clinical challenge and suboptimal techniques of craniofacial bone defects resulting from various conditions, such as congenital malformations, osteomyelitis, trauma and tumor resection, the ongoing research of regenerative medicine using stem cells and concurrent advancement in biotechnology have shifted the focus from surgical reconstruction to a novel stem cell-based tissue engineering strategy for customized and functional craniofacial bone regeneration. Given the unique ontogenetical and cell biological properties of perinatal stem cells, emerging evidence has suggested these extraembryonic tissue-derived stem cells to be a promising cell source for extensive use in regenerative medicine and tissue engineering. In this review, we summarize the current achievements and obstacles in stem cell-based craniofacial bone regeneration and subsequently we address the characteristics of various types of perinatal stem cells and their novel application in tissue engineering of craniofacial bone. We propose the promising feasibility and scope of perinatal stem cell-based craniofacial bone tissue engineering for future clinical application.