Introducing a simplified approach to insulin therapy in type 2 diabetes: a comparison of two single-dose regimens of insulin glulisine plus insulin glargine and oral antidiabetic drugs
Introducing a simplified approach to insulin therapy in type 2 diabetes: a comparison of two single-dose regimens of insulin glulisine plus insulin glargine and oral antidiabetic drugs
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DOI：
10.1111/j.1463-1326.2008.00967.x
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发表时间：
2008-12-01
影响因子：
5.8
通讯作者：
Scherbaum, W. A.
中科院分区：
文献类型：
--
作者：
Lankisch, M. R.;Ferlinz, K. C.;Scherbaum, W. A.
目的：研究单次推注赖谷胰岛素是否（谷赖胰岛素），在早餐或主餐时间给药，与基础甘精胰岛素联合给药（甘精胰岛素）和口服抗糖尿病药物（OAD）在2型糖尿病患者中提供等效的血糖控制，而不考虑谷赖胰岛素注射的时间。一项全国性、多中心、随机、开放标签、平行组研究，纳入了393例血糖控制欠佳[血红蛋白A（1c）（HbA（1c））> 6.5-9.0%和空腹血糖（BG）
Aim: To investigate whether the addition of a single bolus of insulin glulisine (glulisine), administered at either breakfast or main mealtime, in combination with basal insulin glargine (glargine) and oral antidiabetic drugs (OADs), provides equivalent glycaemic control in patients with type 2 diabetes, irrespective of the time of glulisine injection.Methods: A national, multicentre, randomized, open-label, parallel-group study of 393 patients with type 2 diabetes who were suboptimally controlled [haemoglobin A(1c) (HbA(1c)) > 6.5-9.0% and fasting blood glucose (BG)