MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma
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DOI：
10.1007/s00428-011-1041-x
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发表时间：
2011-05-01
期刊：
影响因子：
3.5
通讯作者：
Yamamoto, Nobuyuki
中科院分区：
文献类型：
--
作者：
Kaira, Kyoichi;Murakami, Haruyasu;Yamamoto, Nobuyuki
MUC 1是一种跨膜粘蛋白，与多种恶性肿瘤的进展和结局相关。然而，胸腺上皮肿瘤的临床意义仍然未知。我们研究了MUC 1在胸腺上皮性肿瘤中表达的临床意义。本研究纳入了55例胸腺上皮肿瘤患者。肿瘤切片通过免疫组织化学染色MUC 1、血管内皮生长因子（VEGF）、通过CD 34和p53测定的微血管密度（MVD）。MUC 1的表达率为29%。MUC 1的表达与胸腺上皮性肿瘤的恶性程度密切相关。MUC 1与VEGF、p53和MVD密切相关，MUC 1过表达是预测预后不良的单因素分析指标。MUC 1在胸腺癌中的阳性表达率为94%（16/17），在B3型胸腺瘤中的阳性表达率为0%（0/5），两者之间有显著性差异（p <0.05）。
MUC1 is a transmembrane mucin that has been related to tumor progression and outcome in various malignancies. However, the clinical significance in thymic epithelial tumors remains unknown. We investigated the clinical significance of MUC1 expression in thymic epithelial tumors. Fifty-five patients with thymic epithelial tumors were included in this study. Tumors sections were stained by immunohistochemistry for MUC1, vascular endothelial growth factor (VEGF), microvessel density (MVD) determined by CD34, and p53. MUC1 were expressed in 29%. The expression of MUC1 was significantly correlated with the grade of malignancy in thymic epithelial tumors. MUC1 was closely associated with VEGF, p53 and MVD, and the overexpression of MUC1 was a prognostic marker for predicting poor outcome in univariate analysis. A positive rate of MUC1 expression was 94% (16/17) in thymic carcinomas and 0% (0/5) in type B3 thymomas, demonstrating a significant difference (p