MAGNETIC-RESONANCE-IMAGING OF BLOOD-FLOW WITH A PHASE SUBTRACTION TECHNIQUE - INVITRO AND INVIVO VALIDATION
MAGNETIC-RESONANCE-IMAGING OF BLOOD-FLOW WITH A PHASE SUBTRACTION TECHNIQUE - INVITRO AND INVIVO VALIDATION
复制标题
DOI：
10.1097/00004424-199302000-00004
复制
发表时间：
1993-02-01
影响因子：
6.7
通讯作者：
PELC, NJ
中科院分区：
文献类型：
--
作者：
EVANS, AJ;IWAI, F;PELC, NJ
基本原理和目标。一种有希望的流动量化方法是利用运动质子的速度相关相变。采用一种速度编码相减法技术，测量了幻体中流体流动的速度和流速以及志愿者的血液流动。在一个模型中，作者测量了0.1到270.0厘米/秒的恒定流速，精度（95%置信区间）为+/-12.5厘米/秒。磁共振成像（MRI）测量值与实际值呈线性关系（r2 = 0.99; p = 0.0001）。测量125 ~ 1,900 mL/分钟的平均脉动流量，MRI脉动流量测量的准确度（95%置信区间）为+/-70 mL/分钟。MRI脉搏流量测量值与实际值呈线性关系（r2 = 0.99; P = 0.0001）。在10名正常志愿者身上，作者在体内测试了这项技术，量化了肺动脉和主动脉的流速。两次测量的平均差异为5%。MRI获得的颈动脉血流波形与相应的超声多普勒波形形状吻合较好。速度编码相减法MRI在血流评估方面具有潜在的临床应用价值。潜在的应用将是测定动脉流向实质器官的血流量，检测和量化心内和心外分流，以及快速测定心输出量和每搏量。
RATIONALE AND OBJECTIVES. One promising approach to flow quantification uses the velocity-dependent phase change of moving protons. A velocity-encoding phase subtraction technique was used to measure the velocity and flow rate of fluid flow in a phantom and blood flow in volunteers.METHODS. In a model, the authors measured constant flow velocities from 0.1 to 270.0 cm/second with an accuracy (95% confidence intervals) of +/-12.5 cm/second. There was a linear relationship between the magnetic resonance imaging (MRI) measurement and the actual value (r2 = .99; p = .0001).RESULTS. Measuring mean pulsatile flow from 125 to 1,900 mL/minute, the accuracy of the MRI pulsatile flow measurements (95% confidence intervals) was +/-70 mL/minute. There was a linear relationship between the MRI pulsatile flow measurement and the actual value (r2 = .99; P = .0001). In 10 normal volunteers, the authors tested the technique in vivo, quantitating flow rates in the pulmonary artery and the aorta. The average difference between the two measurements was 5%. In vivo carotid flow waveforms obtained with MRI agreed well with the shape of corresponding ultrasound Doppler waveforms.CONCLUSIONS. Velocity-encoding phase subtraction MRI bears potential clinical use for the evaluation of blood flow. Potential applications would be in the determination of arterial blood flow to parenchymal organs, the detection and quantification of intra- and extra-cardiac shunts, and the rapid determination of cardiac output and stroke volume.