Role of DC-SIGN in Helicobacter pylori infection of gastrointestinal cells.
Role of DC-SIGN in Helicobacter pylori infection of gastrointestinal cells.
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DOI：
10.2741/4250
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Jing Wu;Kai Lin;Jing-Qing Zeng;W. Liu;Fengyu Yang;Xin-qiong Wang;Yuan Xiao;Xiaokui Guo;H. Nie;T. Zhou;Chundi Xu
中科院分区：
文献类型：
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作者：
Jing Wu;Kai Lin;Jing-Qing Zeng;W. Liu;Fengyu Yang;Xin-qiong Wang;Yuan Xiao;Xiaokui Guo;H. Nie;T. Zhou;Chundi Xu
H.幽门螺杆菌引起胃炎，并增加胃溃疡和胃癌的风险。然而，最近的研究表明，H.幽门螺杆菌提供了对炎症性肠病的保护。为了评估这些功能的分子机制，我们研究了DC-SIGN在H.幽门感染的胃肠上皮细胞。DC-SIGN在H. pylori感染并介导Th 1分化，Th 1分化可能与H.幽门致胃粘膜损伤。此外，DC-SIGN在结肠炎小鼠模型肠上皮细胞中也表达上调，但在H. pylori感染，提示H.幽门螺杆菌感染可降低局部和全身炎症反应。因此，我们认为感染H. pylori可能通过转分化过程获得免疫特性，并在DC-SIGN的控制下调节组织相关免疫区室。
H. pylori causes gastritis and increases the risk of gastric ulcer and gastric cancer. However, it was recently shown that H. pylori provides protection against inflammatory bowel diseases. To assess the molecular mechanism of such functions, we studied the role of DC-SIGN in H. pylori-infected gastrointestinal epithelial cells. DC-SIGN was found to be over-expressed in the gastric epithelial cells infected with H. pylori and mediated Th1 differentiation, which may be involved in H. pylori-induced gastric mucosal injury. In addition, DC-SIGN was also up-regulated in the intestinal epithelial cells derived from colitis mouse model, but the expression levels were blocked upon H. pylori infection, indicating that H. pylori infection may reduce both local and systemic inflammatory responses. In conclusion, we propose that gastrointestinal epithelial cells infected with H. pylori may lead to acquiring of immune properties via a trans-differentiation process, and regulate tissue-associated immune compartments under the control of DC-SIGN.