Positive mood enhances reward-related neural activity.
Positive mood enhances reward-related neural activity.
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积极的情绪会增强与奖励相关的神经活动。
DOI：
10.1093/scan/nsw012
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发表时间：
2016
影响因子：
4.2
通讯作者：
Nusslock,Robin
中科院分区：
文献类型：
--
作者：
Young,ChristinaB;Nusslock,Robin
尽管行为研究表明，积极情绪几乎在每个主要生活领域都会带来预期的结果，但没有研究直接检验积极情绪对奖励相关情感和目标导向行为背后的神经过程的影响。为了解决这一差距，本功能磁共振成像研究的参与者经历了积极（n =20）或中性（n =20）情绪诱导，并随后完成了评估奖励和损失处理的货币激励延迟任务。与预测一致，积极情绪会提高皮质纹状体神经区域的奖励预期活动，这些区域与奖励处理和目标导向行为有关，包括伏核、尾状核、外侧眶额皮层和壳核，以及相关的旁边缘区域，包括前岛叶和腹内侧前额叶皮层。在奖励结果、损失预期或损失结果中没有观察到这些影响。重要的是，这是第一项报告积极情绪可以增强与奖励相关的神经活动的研究。我们的研究结果对于揭示积极情绪增强目标导向行为的神经机制、了解与奖励相关的神经活动的可塑性以及开发针对以奖励处理缺陷为特征的精神疾病的针对性治疗方法具有重要意义。
Although behavioral research has shown that positive mood leads to desired outcomes in nearly every major life domain, no studies have directly examined the effects of positive mood on the neural processes underlying reward-related affect and goal-directed behavior. To address this gap, participants in the present fMRI study experienced either a positive (n =20) or neutral (n =20) mood induction and subsequently completed a monetary incentive delay task that assessed reward and loss processing. Consistent with prediction, positive mood elevated activity specifically during reward anticipation in corticostriatal neural regions that have been implicated in reward processing and goal-directed behavior, including the nucleus accumbens, caudate, lateral orbitofrontal cortex and putamen, as well as related paralimbic regions, including the anterior insula and ventromedial prefrontal cortex. These effects were not observed during reward outcome, loss anticipation or loss outcome. Critically, this is the first study to report that positive mood enhances reward-related neural activity. Our findings have implications for uncovering the neural mechanisms by which positive mood enhances goal-directed behavior, understanding the malleability of reward-related neural activity, and developing targeted treatments for psychiatric disorders characterized by deficits in reward processing.