Matrix metalloproteinase-9 is associated with disease-free survival and overall survival in patients with gastric cancer
Matrix metalloproteinase-9 is associated with disease-free survival and overall survival in patients with gastric cancer
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DOI：
10.1002/ijc.25734
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发表时间：
2011-08-15
影响因子：
6.4
通讯作者：
Ji, Gang
中科院分区：
文献类型：
--
作者：
Chu, Dake;Zhang, Zixi;Ji, Gang
基质金属蛋白酶-9是基质金属蛋白酶（Matrix metalloproteinases， MMP）家族的一员，在一些实体肿瘤中过表达，被认为能增强肿瘤的侵袭和转移能力。我们的研究是探讨MMP-9表达与胃癌患者无病生存和总生存的关系。采用免疫组化方法对286例未接受新辅助化疗的胃癌患者的临床标本及邻近正常组织进行了研究。对染色评价结果与各种临床病理特征、无病生存期和总生存期进行统计学分析。胃癌组织中高水平表达MMP-9，明显高于邻近正常上皮细胞。在胃癌中，MMP-9与浸润深度、淋巴结转移及远处转移呈显著正相关。然而，MMP-9的表达与患者的年龄、性别、肿瘤位置和分化状态没有相关性。MMP-9阳性肿瘤患者的无病生存期和总生存期明显短于MMP-9阴性肿瘤患者。多变量分析确定MMP-9是无病生存和总生存的独立预后因素。我们的研究结果为MMP-9在人胃癌复发和预后中发挥重要作用提供了令人信服的证据。它也可能作为预后预测和治疗的新靶点。
Matrix metalloproteinase-9 is a member of the Matrix metalloproteinases (MMP) family, which is overexpressed in some solid tumor and thought to enhance the tumor invasion and metastasis ability. Our study is to investigate the association of MMP-9 expression with disease-free survival and overall survival of patients with gastric cancer. Clinical gastric cancer specimens and adjacent normal tissues from 286 patients who had not received neoadjuvant chemotherapy were investigated by immunohistochemistry assay. Staining evaluation results were analyzed statistically in relation to various clinicopathological characters, disease-free survival and overall survival. High level of MMP-9 expression was detected in gastric cancer, significantly more than in adjacent normal epithelial cells. In gastric cancer, MMP-9 was significantly positively correlated with depth of invasion, lymph node metastasis and distant metastasis. However, no correlations between MMP-9 expression and patients' age, sex, tumor location or differentiation status were detected. The disease-free survival and overall survival were significantly shorter for patients with MMP-9 positive than those with MMP-9 negative tumors. Multivariate analysis identified MMP-9 was an independent prognostic factor for both disease-free survival and overall survival. Our findings provided convincing evidence for MMP-9 as an important role in human gastric cancer recurrence and prognosis. It might also serve as a novel target for both prognostic prediction and therapeutics.