Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration:: a paradox
Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration:: a paradox
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DOI：
10.1016/s0006-8993(98)00882-8
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发表时间：
1998-11-02
期刊：
影响因子：
2.9
通讯作者：
McEwen, BS
中科院分区：
文献类型：
--
作者：
Magariños, AM;Orchinik, M;McEwen, BS
反复应激诱导海马CA 3区锥体神经元顶树突萎缩或重塑。在大鼠中，应激效应被肾上腺类固醇合成抑制剂阻断，并通过每天注射皮质酮来模拟。我们报告说，非侵入性管理的皮质酮在饮用水（400微克/毫升）也产生萎缩的顶端树突在CA 3。出乎意料的是，每日应激和口服皮质酮的组合否定了单独治疗的效果，并且与对照非应激大鼠相比，观察到CA 3锥体神经元的顶端树突长度或分支模式没有变化。(C)1998年由Elsevier Science B. V.出版，版权所有。
Repeated stress induces atrophy, or remodeling, of apical dendrites in hippocampal CA3 pyramidal neurons. In rats, the stress effect is blocked by adrenal steroid synthesis inhibitors, and mimicked by daily injection of corticosterone. We report that non-invasive administration of corticosterone in the drinking water (400 mu g/ml) also produced atrophy of apical dendrites in CA3. Unexpectedly, the combination of daily stress and oral corticosterone negated the effects of either treatment alone, and no changes in the apical dendritic length or branching pattern of CA3 pyramidal neurons were observed compared to control unstressed rats. (C) 1998 Published by Elsevier Science B.V. All rights reserved.