Effects of intravenous histamine on pulmonary mechanics in nonasthmatic and asthmatic subjects.
Effects of intravenous histamine on pulmonary mechanics in nonasthmatic and asthmatic subjects.
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DOI：
10.1152/jappl.1977.42.2.221
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发表时间：
1977-02
期刊：
影响因子：
--
通讯作者：
R. Brown;R. Ingram;J. Wellman;E. Mcfadden
中科院分区：
文献类型：
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作者：
R. Brown;R. Ingram;J. Wellman;E. Mcfadden
组胺被认为是过敏性哮喘气道反应的主要介质之一。我们在非哮喘和哮喘志愿者中详细研究了其静脉输注对肺力学的影响。两组使用的剂量相似，受限于血管效应而非肺效应。测量肺阻力、肺体积细分、最大流量、密度依赖性、肺弹性后坐力和动态顺应性。唯一的平均组变化是非哮喘患者的动态依从性降低和依从性的频率依赖性增加。虽然在非哮喘个体中，某些参数偶尔会发生统计学上显著的变化，但在重复研究中，这种反应是可变的，并且足够小，因此具有可疑的生理意义。一些哮喘患者出现了更大的变化，但这些变化只发生在那些输注前肺功能异常的个体中。我们的研究结果表明，可能是攻击前肺功能的改变而不是对组胺的异常敏感性决定了哮喘患者观察到的更大反应。
Histamine is thought to be one of the primary mediators of the airways response in allergic asthma. We have studied in detail in nonasthmatic and asthmatic volunteers the effects of its intravenous infusion on pulmonary mechanics. The doses used were similar in both groups and limited by vascular rather than pulmonary effects. Measurements were made of lung resistance, the subdivisions of lung volume, maximal flow, density dependence, lung elastic recoil and dynamic compliance. The only mean group changes were a decrease in dynamic compliance and increase in frequency dependence of compliance in the nonasthmatics. Although in nonasthmatic individuals, statistically significant changes occasionally occurred in some parameters, the response was variable on repeated studies and sufficiently small to be of questionable physiological significance. Some of the asthmatics developed larger changes, but these only occurred in those individuals whose preinfusion pulmonary function was abnormal. Our results suggest the possibility that altered prechallenge pulmonary function rather than an unusual sensitivity to histamine may determine the greater responses observed in asthmatics.