Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study.
Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study.
复制标题
患有双相情感障碍的父母未受影响的后代的弱光褪黑激素模式：一项病例对照高风险研究。
DOI：
10.1016/j.jad.2022.07.029
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发表时间：
2022
影响因子：
6.6
通讯作者：
Wing,YunKwok
中科院分区：
文献类型：
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作者：
Feng,Hongliang;Ho,AmyWing-Yin;Lei,Binbin;Chan,JoeyWingYan;Wang,Jing;Liu,Yaping;Tsang,JessieChiChing;Chan,NganYin;Lam,SiuPing;Merikangas,KathleenRies;Ho,ChungShun;Zhang,Jihui;Wing,YunKwok
研究背景昼夜节律失调一直被认为是双相情感障碍（BD）病理生理学的重要组成部分。然而，目前尚不清楚这种失调是否构成BD的风险因素，表现或后果。本研究的目的是比较昏暗的光褪黑激素分泌模式之间的未受影响的后代的父母BD（OBD）和后代的控制父母（OCP）MethodsThis病例对照研究包括未受影响的OBD（平均年龄14.0岁;男性50.0%）和年龄和性别匹配的OCP（平均年龄13.0岁;男性：43.5%）。在昏暗的光线条件下收集了17份唾液样本。结果共采集12例OBD患者185份唾液样本（n = 12）和46例OCP患者741份唾液样本（n = 46）。与OCP相比，未受影响的OBD在DLMO后两小时内具有显著较低的夜间褪黑激素水平（14.8 ± 4.6 vs. 20.3 ± 11.7 pg/mL）和较小的褪黑激素AUC（35.5 ± 11.3 vs. 44.6 ± 18.1 pg/mL），但DLMO和睡眠开始之间的相位角显著较大（2.2 ± 1.0 vs. 1.4 ± 1.2 h）。DLMO无显著组间差异。图示显示了一个相当平坦的褪黑激素分泌在未受影响的OBD.LimitationsThe主要的局限性，包括缺乏24小时暗淡的褪黑激素分泌测量，大年龄范围的参与者，和小样本size.ConclusionsThese研究结果表明，未受影响的OBD已经提出了昼夜节律失调。未来的研究需要澄清的作用，异常褪黑激素分泌的发病BD。
BackgroundCircadian dysregulation has long been thought to be a key component in the pathophysiology of bipolar disorder (BD). However, it remains unclear whether this dysregulation constitutes a risk factor, manifestation, or consequence of BD. This study aimed to compare dim light melatonin secretion patterns between unaffected offspring of parents with BD (OBD) and offspring of control parents (OCP).MethodsThis case-control study included unaffected OBD (mean age 14.0 years; male 50.0 %) and age- and sex-matched OCP (mean age 13.0 years; male: 43.5 %). Seventeen saliva samples were collected in dim light conditions. Dim light melatonin onset (DLMO), phase angles, and area under the curve (AUC) were calculated.Results185 saliva samples from 12 OBD (n = 12) and 741 from OCP (n = 46) were collected. Unaffected OBD had a significant lower nocturnal melatonin level (14.8 ± 4.6 vs. 20.3 ± 11.7 pg/mL) and a smaller melatonin AUC within two hours after DLMO (35.5 ± 11.3 vs. 44.6 ± 18.1 pg/mL) but a significant larger phase angle between DLMO and sleep onset (2.2 ± 1.0 vs. 1.4 ± 1.2 h) than OCP. There was no significant between-group difference in DLMO. The graphic illustrations showed a considerably flattened melatonin secretion in unaffected OBD.LimitationsThe main limitations include lack of 24-h dim melatonin secretion measurement, large age range of participants, and small sample size.ConclusionsThese findings suggest that unaffected OBD already presented with circadian rhythm dysregulations. Future investigations are needed to clarify the role of abnormal melatonin secretion in the onset of BD.