Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging
Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging
复制标题
DOI：
10.1364/oe.17.021414
复制
发表时间：
2009-11-23
期刊：
影响因子：
3.8
通讯作者：
Razansky, Daniel
中科院分区：
文献类型：
--
作者：
Ma, Rui;Taruttis, Adrian;Razansky, Daniel
全身光声成像的一个主要困难是与记录来自多个空间投影的信号相关的长采集时间。所获取的信号通常也较弱，信噪比较低，这些问题通常通过信号平均来解决，这使获取复杂化，并将获取时间增加到使许多体内应用具有挑战性或甚至不可能的程度。在这里，我们提出了一种快速采集多光谱光声断层扫描（MSOT）扫描仪全身可视化的分子标记物在小动物。多波长照明提供了解析外源施用的荧光探针、生物标志物和其他内在和外源发色团的可能性。该系统的性能是在涉及分子探针的幻影实验中确定的，并通过对各种尺度的小动物进行成像来验证。(C)2009年美国光学学会
A major difficulty arising from whole-body optoacoustic imaging is the long acquisition times associated with recording signals from multiple spatial projections. The acquired signals are also generally weak and the signal-to-noise-ratio is low, problems often solved by signal averaging, which complicates acquisition and increases acquisition times to an extent that makes many in vivo applications challenging or even impossible. Herein we present a fast acquisition multispectral optoacoustic tomography (MSOT) scanner for whole-body visualization of molecular markers in small animals. Multi-wavelength illumination offers the possibility to resolve exogenously administered fluorescent probes, biomarkers, and other intrinsic and exogenous chromophores. The system performance is determined in phantom experiments involving molecular probes and validated by imaging of small animals of various scales. (C) 2009 Optical Society of America