LIMBIC AND PREFRONTAL CONTRIBUTIONS TO SOMESTHETIC LEARNING IN MONKEYS
LIMBIC AND PREFRONTAL CONTRIBUTIONS TO SOMESTHETIC LEARNING IN MONKEYS
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DOI：
10.1016/0006-8993(77)90199-8
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发表时间：
1977-01-01
期刊：
影响因子：
2.9
通讯作者：
MISHKIN, M
中科院分区：
文献类型：
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作者：
DEUEL, R;MISHKIN, M
将前脑连合切除术和右半球颞侧、颞内侧、背侧前额叶或腹侧前额叶切除术的猴[猕猴]与对照动物在学习触觉辨别和左手翻转方面进行比较。侧颞切除没有产生任何影响，证实了该部门在听力（上级颞回）和视觉（颞下回）的模态特定的作用。背侧前额叶切除产生了赤字的歧视学习，可能是由于对侧的感觉忽视或空间障碍产生的这种病变。剩下的2个病变，内侧颞叶和腹侧前额叶，都产生了赤字的歧视学习和逆转，这2个边缘系统部门的联合删除的影响似乎是加性的。结合视觉和听力方面的早期发现，结果表明，这两个边缘系统有助于所有感觉方式的学习，并且它们通过与感觉系统的皮质-皮质相互作用来实现这一目标。
Monkeys [Macaca mulatta] with forebrain commissurotomies and either lateral temporal, medial temporal, dorsal prefrontal, or ventral prefrontal removals from the right hemisphere were compared with control animals in learning tactual discriminations and reversal with the left hand. The lateral temporal removal yielded no effect, confirming the modality-specific roles of this sector in audition (superior temporal gyrus) and vision (inferior temporal gyrus). The dorsal prefrontal removal yielded a deficit in discrimination learning, possibly as a result of the contralateral sensory neglect or the spatial disorder produced by this lesion. Each of the 2 remaining lesions, medial temporal and ventral prefrontal, yielded deficits in both discrimination learning and reversal; and the effects of combined removal of these 2 limbic sectors appeared to be additive. Taken together with earlier findings in vision and audition, the results indicate that the 2 limbic sectors contribute to learning in all sensory modalities, and that they do so through cortico-cortical interaction with the sensory systems.