Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes.
Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes.
复制标题
DOI：
10.1155/2017/8724869
复制
发表时间：
2017
影响因子：
2.8
通讯作者：
Tu P
中科院分区：
文献类型：
--
作者：
Duan P;Yang M;Wei M;Liu J;Tu P
本研究旨在探讨绝经后糖尿病及前驱糖尿病妇女血清OPG水平及其与胰岛素抵抗的关系。本研究共招募了271名无血缘关系的中国绝经后妇女。根据血糖调节类别的不同，将受试者分为2型糖尿病（T2DM）组（n = 93）、血糖调节受损组（n = 90）和血糖调节正常组（n = 88）。采用酶联免疫吸附法测定血清OPG水平。NGR组血清OPG浓度为151.00±45.72 pg/mL，显著低于IGR组（169.28±64.91 pg/mL） （p = 0.031）和T2DM组（183.20±56.53 pg/mL） （p < 0.01）。多元线性回归分析发现HOMA-IR、年龄、2hPG、AST、ALP和eGFR是OPG的独立预测因子。血清OPG水平升高（OR = 1.009, p = 0.006）可能是胰岛素抵抗的危险因素。本研究表明，OPG可能与糖尿病的发病机制有关，并且是糖尿病和前驱糖尿病患者胰岛素抵抗的潜在生物标志物。
The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (n = 93), impaired glucose regulation (IGR) (n = 90), and normal glucose regulation group (NGR) (n = 88), according to different glucose regulation categories. Serum OPG levels were measured by enzyme-linked immunosorbent assay. The serum OPG concentration in NGR group, 151.00 ± 45.72 pg/mL, was significantly lower than that in IGR group (169.28 ± 64.91 pg/mL) (p = 0.031) and T2DM group (183.20 ± 56.53 pg/mL) (p < 0.01), respectively. In multiple linear regression analysis, HOMA-IR, age, 2hPG, AST, ALP, and eGFR were found to be independent predictors of OPG. Increased serum OPG levels (OR = 1.009, p = 0.006) may be a risk factor for insulin resistance. The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.