Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism.
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism.
复制标题
肠道微生物群形成短链脂肪酸及其对人代谢的影响。
DOI：
10.1080/19490976.2015.1134082
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发表时间：
2016-05-03
期刊：
影响因子：
12.2
通讯作者：
Preston T
中科院分区：
文献类型：
--
作者：
Morrison DJ;Preston T
SCFA的形成是饮食与肠道内腔环境内肠道微生物群之间复杂相互作用的结果。在一系列细胞和组织类型中发现短链脂肪酸SCFA似乎是天然配体的受体，导致对SCFA作为肠道微生物群和宿主之间的信号分子的兴趣增加。SCFA代表了从饮食通过肠道微生物群到宿主的主要碳通量，并且正在出现SCFA在局部、中间和外周代谢中的调节作用的证据。然而，缺乏精心设计和控制的人体研究阻碍了我们对SCFA在人类代谢健康中的重要性的理解。这篇综述旨在将SCFA在人体代谢中的作用的最新研究结果汇总在一起，以突出SCFA在不同代谢系统中的多方面作用。
The formation of SCFA is the result of a complex interplay between diet and the gut microbiota within the gut lumen environment. The discovery of receptors, across a range of cell and tissue types for which short chain fatty acids SCFA appear to be the natural ligands, has led to increased interest in SCFA as signaling molecules between the gut microbiota and the host. SCFA represent the major carbon flux from the diet through the gut microbiota to the host and evidence is emerging for a regulatory role of SCFA in local, intermediary and peripheral metabolism. However, a lack of well-designed and controlled human studies has hampered our understanding of the significance of SCFA in human metabolic health. This review aims to pull together recent findings on the role of SCFA in human metabolism to highlight the multi-faceted role of SCFA on different metabolic systems.