Epigenetic dynamics in immunity and autoimmunity.
Epigenetic dynamics in immunity and autoimmunity.
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DOI：
10.1016/j.biocel.2015.05.022
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Ming Zhao;Zijun Wang;S. Yung;Q. Lu
中科院分区：
文献类型：
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作者：
Ming Zhao;Zijun Wang;S. Yung;Q. Lu
基因组DNA和染色质内的调控蛋白之间的紧密同步和时空相互作用对于细胞定型和分化是必不可少的。在免疫系统的发育和激活期间，涉及谱系指导性转录因子的诱导、组蛋白修饰的安装或去除以及DNA甲基化模式的变化的复杂调控网络局部地协调三维染色质结构并决定免疫细胞命运和免疫应答。在自身免疫性疾病中，疾病相关的表观遗传标记和动态变化控制着失调的免疫系统，从而决定了疾病的发展和临床表型。本文介绍了DNA和组蛋白的动态表观遗传调控，总结了一些重要免疫细胞亚群发育和分化的表观遗传调控机制，为系统性红斑狼疮、类风湿性关节炎、多发性硬化症和1型糖尿病等自身免疫性疾病的发病机制提供了新的见解。发育和疾病中的表观遗传学动力学。
A tightly synchronized and spatial-temporal interaction among regulatory proteins within genomic DNA and chromatin is essential for cellular commitment and differentiation. During development and activation of the immune system, a complex regulatory network that involves induction of lineage instructive transcription factors, installation or removal of histone modifications and changes in DNA methylation patterns locally orchestrate the three-dimensional chromatin structure and determine immune cell fate and immune responses. In autoimmune diseases, disease associated epigenetic marks and dynamic changes control the dysregulated immune system, thus determining the disease development and clinical phenotype. In this review, we introduce the dynamic epigenetic regulation of DNA and histones, summarize the epigenetic regulatory mechanisms in the development and differentiation of some important immune cell subsets and provide new insights for the pathogenesis of autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and Type 1 diabetes.This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.