Response to "is high prorenin level related to relative aldosterone excess?".
Response to "is high prorenin level related to relative aldosterone excess?".
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回答“高肾素原水平与相对醛固酮过量有关吗？”。
DOI：
10.1093/ajh/hps059
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发表时间：
2013
影响因子：
3.2
通讯作者：
Danser,AHJan
中科院分区：
文献类型：
--
作者：
Tu,Wanzhu;Eckert,GeorgeJ;Pratt,JHoward;Danser,AHJan
致编辑：我们要感谢Satoh博士及其同事对我们最近的研究“黑人和白人的血浆前肾素和肾素水平：它们的相对减少和与血浆醛固酮浓度的关联”的兴趣。[1]我们报道了黑人和白人的血浆肾素原水平相似，但黑人的血浆肾素浓度（PRC）明显低于白人，且血浆肾素原与血浆醛固酮浓度（PAC）呈负相关。佐藤博士在给编辑的信中建议，我们应该进一步研究原肾素和醛固酮与血浆肾素活性比（醛固酮/肾素比，或ARR）之间的关系，以表明原肾素可能在醛固酮相对过量中发挥作用，特别是在黑人中，他们被认为更容易患盐敏感型高血压。我们赞赏这一建议，并同意这是一个合乎逻辑和可能重要的问题，应在后续分析中加以处理。
To the Editor: We would like to thank Dr. Satoh and colleagues for their interest in our recent study titled “Plasma Levels of Prorenin and Renin in Black and Whites: Their Relative Abundance and Associations with Plasma Aldosterone Concentration.” 1 We reported that blacks and whites had similar plasma prorenin levels, but that in blacks the plasma renin concentration (PRC) was markedly lower, and prorenin was negatively associated with plasma aldosterone concentration (PAC). In their Letter to the Editor, Dr. Satoh suggested we should further examine the association between prorenin and aldosterone to plasma renin activity ratio (aldosterone/renin ratio, or ARR), for indication that prorenin might have played a role in the relative excess of aldosterone, especially in blacks, who are thought to be more susceptible to a salt-sensitive form of hypertension. We appreciate this suggestion and agree that this is a logical and potentially important question that should be addressed in a follow-up analysis.