Recent progresses in marine microbial-derived antiviral natural products.
Recent progresses in marine microbial-derived antiviral natural products.
复制标题
海洋微生物抗病毒天然产物研究进展
DOI：
10.1007/s12272-020-01286-3
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发表时间：
2020-12
影响因子：
6.7
通讯作者：
Shao CL
中科院分区：
文献类型：
--
作者：
Teng YF;Xu L;Wei MY;Wang CY;Gu YC;Shao CL
病毒一直是世界范围内威胁人类健康和生命安全的一类病原微生物。然而，长期以来，病毒感染的治疗发展缓慢，临床上使用的抗病毒药物寥寥无几。与陆地微生物相比，海洋微生物可以产生结构更新颖、功能更独特的活性物质。2015年至2019年，从海洋微生物中分离得到8个结构类别的89个抗病毒化合物，其中35个化合物具有抗H1N1病毒活性。该综述系统地综述了海洋微生物衍生的具有抗病毒活性的天然产物，并说明了这些化合物在抗病毒药物发现研究中的影响。
Viruses have always been a class of pathogenic microorganisms that threaten the health and safety of human life worldwide. However, for a long time, the treatment of viral infections has been slow to develop, and only a few antiviral drugs have been using clinically. Compared with these from terrestrial environments, marine-derived microorganisms can produce active substances with more novel structures and unique functions. From 2015 to 2019, 89 antiviral compounds of 8 structural classes have been isolated from marine microorganisms, of which 35 exhibit anti-H1N1 activity. This review surveys systematically marine microbial-derived natural products with antiviral activity and illustrates the impact of these compounds on antiviral drug discovery research.