Determinants of maximal inspiratory pressure in chronic obstructive pulmonary disease.
Determinants of maximal inspiratory pressure in chronic obstructive pulmonary disease.
复制标题
慢性阻塞性肺疾病最大吸气压的决定因素。
DOI：
--
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
N. Braun
中科院分区：
文献类型：
--
作者：
D. Rochester;N. Braun
COPD患者的吸气肌力量可能会降低，这可能是由于肺容量增加导致的机械缺陷，也可能是因为呼吸肌存在全身性肌无力。为了评估这些因素的相对贡献，我们分别在32例COPD患者中测量了RV和TLC处的最大吸气和呼气压力（Pimax，Pemax，cmH 2 O）。用X线摄影测定TLC、RV和RV处膈肌长度指数（DLI，cm/cm高），并与22例肺容量相当的正常人的值进行比较。一半COPD患者的Pemax值正常，一半患者的Pemax值较低，但两组患者的TLC、RV和DLI值相似。在COPD患者中，Pimax与Pemax（r = 0.73）和DLI（r = 0.64）相关（p <0.001）。Pimax-DLI关系的斜率在两组COPD患者中与正常受试者基本相同。然而，在任何DLI值下，Pemax正常患者的Pimax均在正常范围内，但Pemax较低患者的Pimax显著较低（p <0.001）。将Pimax表示为Pemax和DLI的组合函数产生了最高的相关性（r = 0.84，p小于0.001），Pemax解释了46%的Pimax方差，DLI解释了35%的Pimax方差，而其他变量无法单独解释（p小于0.001）。18例Pimax <55 cm H2O的患者中，13例PaCO 2升高，与Pimax呈负相关（r =-0.66，p <0.005）。（250字处删节）
Inspiratory muscle strength in COPD could be reduced either because of mechanical disadvantage consequent to increased lung volume or because respiratory muscles share in generalized muscle weakness. To assess the relative contributions of these factors, we measured maximal inspiratory and expiratory pressures (Pimax, Pemax, cmH2O) at RV and TLC, respectively, in 32 patients with COPD. The TLC, RV, and diaphragm length index at RV (DLI, cm/cm height) were determined roentgenographically and compared with values from 22 normal subjects studied at comparable lung volume. Half the patients with COPD had normal and half had low values of Pemax, but both groups had similar values of TLC, RV, and DLI. In patients with COPD, Pimax correlated (p less than 0.001) with Pemax (r = 0.73) and DLI (r = 0.64). The slope of the Pimax-DLI relationship was essentially the same in both groups of patients with COPD as it was in the normal subjects. However, at any value of DLI, Pimax was in the normal range in patients with normal Pemax, but significantly lower in patients with low Pemax (p less than 0.001). Expressing Pimax as a combined function of Pemax and DLI yielded the highest correlation (r = 0.84, p less than 0.001), with Pemax explaining 46% and DLI explaining 35% of the variance in Plmax not explained by the other variable alone (p less than 0.001). The PaCO2 was elevated in 13 of 18 patients whose Pimax was less than 55 cm H2O, and inversely correlated with Pimax (r = -0.66, p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
哺乳动物膈肌的长度-张力关系。
DOI：
10.1152/jappl.1983.54.6.1681
发表时间：
1983
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
McCully,KK;Faulkner,JA
通讯作者：
Faulkner,JA
弹性蛋白酶诱导的肺气肿对膈肌产生力的能力的影响。
DOI：
10.1172/jci110709
发表时间：
1982
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Supinski,GS;Kelsen,SG
通讯作者：
Kelsen,SG