Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
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DOI：
10.1016/j.devcel.2005.05.016
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发表时间：
2005-08-01
影响因子：
11.8
通讯作者：
McMahon, AP
中科院分区：
文献类型：
--
作者：
Carroll, TJ;Park, JS;McMahon, AP
脊椎动物泌尿生殖系统的形成是由于沃尔夫管、其衍生物输尿管芽和它们相邻的间充质之间的诱导相互作用。这些在中肾（胚胎）和后肾（成人）肾脏和苗勒管（雌性生殖道的原基）内建立上皮原基。我们发现，Wnt9b在诱导上皮细胞中表达，并且对于中肾和后肾小管的发育以及苗勒管的尾部延伸是必不可少的。Wnt9b是后肾间充质最早的诱导反应所必需的。此外，表达Wnt9b的细胞可以在这些相互作用中功能性地替代输尿管芽。Wnt9b在这个过程中作用于另一个Wnt，Wnt4的上游，我们的数据表明经典Wnt信号传导是哺乳动物泌尿生殖系统组织中的主要途径之一。总之，这些发现表明，Wnt9b是一个共同的组织信号调节哺乳动物泌尿生殖系统的不同组成部分。
The vertebrate urogenital system forms due to inductive interactions between the Wolffian duct, its derivative the ureteric bud, and their adjacent mesenchymes. These establish epithelial primordia within the mesonephric (embryonic) and metanephric (adult) kidneys and the Mullerian duct, the anlage of much of the female reproductive tract. We show that Wnt9b is expressed in the inductive epithelia and is essential for the development of mesonephric and metanephric tubules and caudal extension of the Mullerian duct. Wnt9b is required for the earliest inductive response in metanephric mesenchyme. Further, Wnt9b-expressing cells can functionally substitute for the ureteric bud in these interactions. Wnt9b acts upstream of another Wnt, Wnt4, in this process, and our data implicate canonical Wnt signaling as one of the major pathways in the organization of the mammalian urogenital system. Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system.