Clinico-pathological profile in the infants and children in dengue 2012 epidemic, Kolkata -
Clinico-pathological profile in the infants and children in dengue 2012 epidemic, Kolkata -
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2012 年加尔各答登革热流行期间婴儿和儿童的临床病理学特征 -
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Ghosh Shibendu
中科院分区：
文献类型：
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作者：
S. Ashis;Ghosh Shibendu
背景：登革热(DF)是印度不同地区周期性和频繁流行的主要原因。1992年，大量儿童死于登革出血热。目的与目的：本研究旨在评估2012年加尔各答登革热疫情婴幼儿的人口学和临床病理特征。材料和方法：共233例患者，年龄1~18岁，非结构蛋白1抗原阳性或登革热免疫球蛋白阳性。入院当天和入院后24~48h分别采血进行血液学和生化检查。我们根据血小板计数将登革热患者分为DF和DHF。结果：男女比例为1：0.86，DF/DHF比例为1：3.5。DF和DHF的平均年龄分别为10.31±5.41岁和12.6±4.51岁。DF和DHF患者平均发热天数分别为5.33±1.13天和6.08±1.79天。头痛、背痛、恶心/呕吐、皮疹、食欲不振、松弛运动在DF中有统计学意义。虽然止血带试验在DHF患者中显著阳性(76.92%)，但只有13例患者有出血迹象。DHF和DF患者的红细胞压积(Hct)分别在30~40和30以下显著。白血球减少和肝酶升高(SGOT和SGPT)在DF和DHF患者中都很常见。肝肿大的发生率为13.72%，单纯肝肿大的发生率为4.94%，腹水发生率为1.64%，合并肝肿大和胸腔积液的发生率分别为3.29%和7.14%。结论：在血清阳性的DHF患者中，发热、头痛、背痛、松弛活动是肝肿大、肝酶升高和血浆漏的主要症状。
Background: Dengue fever (DF) is responsible for cyclical and frequent epidemic in different parts of India in its varieties of presentations. In 1992 large number of children died of Dengue hemorrhagic fever (DHF). Aims and objective: In this study, we evaluated the demography and clinico-pathological profile in dengue affected infants and children in 2012 Kolkata epidemic. Materials and methods: Total 233 patients (between 1-18 years, with either Non structural protein 1 antigen or dengue Immunoglobulin positive) admitted in our hospital. After taking proper history and physical examination, blood were sent for different hematological and biochemical examinations on the day of admission and after 24-48 hours of admission. We differentiated the dengue patients into DF and DHF based on platelet count. Results: Male female ratio and DF to DHF ratio were 1: 0.86 and 1: 3.5 respectively. Mean age of DF and DHF were 10.31±5.41 years and 12.6±4.51 years respectively. Mean duration of fever in DF and DHF cases were 5.33±1.13 and 6.08±1.79 days respectively. Headache, backache, nausea/vomiting, rash, anorexia, loose motions were statistically significant in DF. In spite of significant positive tourniquet test in DHF patients (76.92%), only 13 patients showed evidence of bleeding. Hematocrit (Hct) values between 30-40 and below 30 were significant in DHF and DF patients respectively. Leucopenia and increased liver enzymes (SGOT and SGPT) were commonly observed in both DF and DHF patients. Hepatomegaly was observed in 13.72% of DF patients, whereas, isolated hepatomegaly, ascites, combined hepatomegaly with ascites and evidence of pleural effusion were observed in 4.94%, 1.64%, 3.29% and 7.14% of DHF patients respectively. Conclusion: In seropositive DHF patients, fever, headache, backache, loose motions were the predominant symptoms associated with hepatomegaly, elevated liver enzymes and evidence of plasma leakage.
影响因子：
6.4
作者：
Kalayanarooj, S;Vaughn, DW;Ennis, FA
通讯作者：
Ennis, FA