Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis.
Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis.
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通过抑制前列腺素合成来关闭早产儿的动脉导管。
DOI：
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发表时间：
1976
影响因子：
158.5
通讯作者：
N. Silverman
中科院分区：
文献类型：
--
作者：
M. Heymann;A. Rudolph;N. Silverman
前列腺素合成的抑制收缩子宫内胎羊的动脉导管。我们给18名患有动脉导管未闭的早产儿服用抑制剂阿司匹林或吲哚美辛，并通过临床和超声心动图（左心房/心房根部比率）评估其效果。服用阿司匹林（每公斤20毫克，每6小时一次，共4次）后，一名婴儿的导管在24小时内永久关闭;另一名婴儿的导管收缩，临床症状改善，第三名婴儿没有反应。在5名婴儿给予0.3毫克每公斤吲哚美辛，完全关闭发生在一天内，其中两人，谁收到三个剂量有一个星期的血清肌酐升高。在一个婴儿的导管重新开放，需要第二次剂量的吲哚美辛后11天的第一。10名婴儿接受了每公斤0.1毫克的吲哚美辛，8名婴儿在24至30小时内闭合。一个有四天的轻微杂音，一个对两个剂量的吲哚美辛没有反应。三名婴儿在三到七天后再次出现杂音，但只有一名婴儿需要进一步治疗。在接受0.3 mg/kg单次剂量或0.1 mg/kg一次或多次剂量的婴儿中，肾功能未发生变化。
Inhibition of prostaglandin synthesis constricts the ductus arteriosus in fetal lambs in utero. We administered the inhibitors, aspirin or indomethacin to 18 premature infants with patent ductus arteriosus, and assessed the effects clinically and by echocardiography (left atrial/aortic-root ratio). After aspirin (20 mg per kilogram, every six hours for four doses) the ductus closed permanently in one infant within 24 hours; in another, constriction occurred with clinical improvement, and the third did not respond. In five infants given 0.3 mg per kilogram of indomethacin, complete closure occurred within one day; two of them, who received three doses had an elevated serum creatinine for one week. In one infant the ductus reopened, requiring a second dose of indomethacin 11 days after the first. Ten infants received 0.1 mg per kilogram of indomethacin, and closure occurred within 24 to 30 hours in eight. One had a soft murmur for four days, and one did not respond to two doses of indomethacin. A murmur reappeared after three to seven days in three infants but only one required further treatment. In infants receiving a single dose of 0.3 mg per kilogram, or one or more doses of 0.1 mg per kilogram, renal function was unaltered.