Associations between changes in the maternal gut microbiome and differentially methylated regions of diabetes-associated genes in fetuses: A pilot study from a birth cohort study.
Associations between changes in the maternal gut microbiome and differentially methylated regions of diabetes-associated genes in fetuses: A pilot study from a birth cohort study.
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DOI：
10.1111/jdi.12598
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发表时间：
2017-07
影响因子：
3.2
通讯作者：
Mori C
中科院分区：
文献类型：
--
作者：
Tachibana K;Sakurai K;Watanabe M;Miyaso H;Mori C
一些宫内环境因素可增加未来患2型糖尿病的风险。微生物组可以影响健康和疾病之间的平衡。然而，母体肠道微生物组对胎儿未来患糖尿病风险的影响尚不清楚。本研究调查了母体肠道微生物组与脐带样本中糖尿病相关基因的差异甲基化区域之间的关联。本研究纳入了来自出生队列研究的10名妊娠受试者。对母亲粪便样本进行16S核糖体核糖核酸宏基因组分析，并对脐带样本进行脱氧核糖核酸甲基化测定。目前的研究发现，脐带样本中UBE 2E2和KCNQ1甲基化率的变化与母体肠道中厚壁菌门的比例相关，尽管在调整年龄和体重指数后存在边缘相关性。这些发现表明，胎儿中糖尿病相关基因的甲基化与妊娠期间母体微生物群成分之间存在联系。
Several intrauterine environmental factors can increase the future risk of type 2 diabetes. The microbiome can influence the balance between health and disease. However, the influence of the maternal gut microbiome on the future risk of diabetes in the fetus is unknown. The present study investigated the associations between maternal gut microbiome and differentially methylated regions of diabetes‐associated genes in umbilical cord samples. The present study included 10 pregnant participants from a birth cohort study. 16S ribosomal ribonucleic acid metagenome analysis of maternal stool samples and deoxyribonucleic acid methylation assays of umbilical cord samples were carried out. The present study found that changes in the UBE2E2 and KCNQ1 methylation rates in umbilical cord samples were associated with the proportion of Firmicutes in the maternal gut, albeit with marginal correlations after adjustment for age and body mass index. These findings suggest a link between the methylation of diabetes‐associated genes in fetuses and maternal microbiota components during pregnancy.