CIS-PLATINUM OTOTOXICITY
CIS-PLATINUM OTOTOXICITY
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DOI：
10.3109/15563657808988252
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发表时间：
1978-01-01
影响因子：
3.3
通讯作者：
CVITKOVIC, E
中科院分区：
文献类型：
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作者：
HELSON, L;OKONKWO, E;CVITKOVIC, E
The incidence and spectrum of ototoxicity secondary to cis-Pt administration in 104 cancer patients ranging in age from 8-78 yr were determined. Pure tone thresholds from 500-8000 Hz were evaluated prior to and following cis-Pt administration. The most sensitive frequencies were 6000 and 8000 Hz. Younger patients had lower threshold increases per administered dose than older patients. High drug dosages caused larger threshold elevations and extended to lower frequencies. Prehydration and mannitol infusion did not alter ototoxicity. Audiographic evaluation appears necessary for monitoring the treatment of cancer patients with cis-Pt.
