Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.
Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.
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DOI：
10.1007/s00787-015-0759-4
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发表时间：
2016-05
影响因子：
6.4
通讯作者：
Thomason ME
中科院分区：
文献类型：
--
作者：
Marusak HA;Kuruvadi N;Vila AM;Shattuck DW;Joshi SH;Joshi AA;Jella PK;Thomason ME
童年创伤是精神疾病的主要诱发因素。新出现的数据表明，压力易感性是由基因决定的，而风险是由边缘系统脑回路的变化介导的。有必要确定疾病脆弱性的标志物，并且在儿童和青少年时期调查这些标志物至关重要，因为此时神经网络特别具有可塑性，并且经常出现精神疾病。在这项初步研究中，我们评估了脑源性神经营养因子（BDNF）基因的常见变体（Val 66 Met; rs 6265）是否与儿童创伤相互作用，以预测55名社会人口学风险高的青少年样本的边缘灰质体积。我们在右侧胼胝体下区和右侧海马中发现了创伤与BDNF的相互作用，其中BDNF相关的灰质变化在没有创伤史的年轻人中很明显。在没有创伤暴露的年轻人中，海马体积较小与焦虑症状较高有关。这些数据提供了一个共同的BDNF基因变异的神经相关的高风险的城市青年中的童年创伤的贡献的初步证据。生命早期边缘系统结构的改变可能为神经功能障碍的长期模式奠定基础，并对理解创伤应激对发育中大脑的精神和心理生物学后果具有影响。
Childhood trauma is a major precipitating factor in psychiatric disease. Emerging data suggest that stress susceptibility is genetically determined, and that risk is mediated by changes in limbic brain circuitry. There is a need to identify markers of disease vulnerability, and it is critical that these markers be investigated in childhood and adolescence, a time when neural networks are particularly malleable and when psychiatric disorders frequently emerge. In this preliminary study, we evaluated whether a common variant in the brain-derived neurotrophic factor (BDNF) gene (Val66Met; rs6265) interacts with childhood trauma to predict limbic gray matter volume in a sample of 55 youth high in sociodemographic risk. We found trauma-by-BDNF interactions in the right subcallosal area and right hippocampus, wherein BDNF-related gray matter changes were evident in youth without histories of trauma. In youth without trauma exposure, lower hippocampal volume was related to higher symptoms of anxiety. These data provide preliminary evidence for a contribution of a common BDNF gene variant to the neural correlates of childhood trauma among high-risk urban youth. Altered limbic structure in early life may lay the foundation for longer-term patterns of neural dysfunction, and hold implications for understanding the psychiatric and psychobiological consequences of traumatic stress on the developing brain.