Breathing during sleep in patients with interstitial lung disease.
Breathing during sleep in patients with interstitial lung disease.
复制标题
间质性肺疾病患者睡眠期间的呼吸。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
M. Kryger
中科院分区：
文献类型：
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作者：
R. Perez;P. West;M. Lertzman;M. Kryger
间质性肺疾病 (ILD) 患者在清醒时会出现快速浅呼吸模式，这被认为是由于肺反射激活所致。我们想知道睡眠是否会导致呼吸控制的改变，从而导致低氧血症和睡眠质量差。 11 名 ILD 患者（5 名男性和 6 名女性）和 11 名年龄和性别匹配的对照受试者在睡眠期间进行了研究。 ILD 患者的睡眠质量较差，与对照受试者相比，第一阶段的时间更长（总睡眠时间 (TST) 的 33.7% 与 13.5%），快速眼动睡眠时间更少（TST 分别为 11.8% 与 19.9%），且睡眠碎片化程度更高（每小时唤醒 13.7 +/- 3.1 次，每小时睡眠阶段变化 24.3 +/- 6.0 次，每小时 6.9 +/- 1.0 次）和 12.7 +/- 1.4，分别）。清醒时 SaO2 低于 90% 的 ILD 患者比 SaO2 高于 90% 的 ILD 患者睡眠结构异常更严重。 ILD 患者呼吸暂停和低通气期的发生率较低（呼吸暂停加通气不足指数为 1.3 +/- 0.45，对照受试者为 2.9 +/- 0.82，p = NS）。患者在快速眼动睡眠期间血氧饱和度下降，尤其是那些患有更严重的清醒低氧血症的患者。患者的呼气时间 (Te)、吸气时间 (Ti) 及其总和 (Ttot) 较短，而 Ti/Ttot 与对照组相同。这些变量在睡眠期间没有出现系统性变化。吸气量指数、Ti、Te 和 Ti/Ttot 的变异性与对照组相似，并且在 NREM 睡眠期间最低。患者和对照组的打鼾发生率相当。（摘要截断为 250 字）
Patients with interstitial lung disease (ILD) have a rapid shallow breathing pattern while awake that is thought to be due to activation of lung reflexes. We wondered whether sleep would result in changes in respiratory control and thus cause hypoxemia and poor sleep quality. Eleven patients with ILD (5 men and 6 women) and 11 age- and sex-matched control subjects were studied during sleep. Sleep quality was worse in patients with ILD, with more time in Stage 1 (33.7% of total sleep time (TST) versus 13.5%) and less time in REM sleep (11.8 versus 19.9% TST) than found in control subjects, and more fragmentation of sleep (13.7 +/- 3.1 arousals/h and 24.3 +/- 6.0 sleep stage changes/h versus 6.9 +/- 1.0 and 12.7 +/- 1.4, respectively). Patients with ILD with awake SaO2 less than 90% had greater abnormalities in sleep structure than did those with SaO2 greater than 90%. The incidence of apneas and hypopnea periods in patients with ILD was low (apnea plus hypoventilation index of 1.3 +/- 0.45 versus 2.9 +/- 0.82 in control subjects, p = NS). Oxygen saturation dropped during REM sleep in patients, especially in those with more severe awake hypoxemia. Expiratory time (Te), inspiratory time (Ti), and their sum (Ttot) were shorter in the patients, whereas Ti/Ttot was the same as in control subjects. No systematic changes during sleep were seen in these variables. The variability of inspiratory volume index, Ti, Te, and Ti/Ttot was similar to that in control subjects, and was lowest during NREM sleep. The incidence of snoring was comparable in patients and control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)