Different characteristics of gustatory responses between the greater superficial petrosal and chorda tympani nerves in the rat
Different characteristics of gustatory responses between the greater superficial petrosal and chorda tympani nerves in the rat
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DOI：
10.1093/chemse/22.2.133
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发表时间：
1997-04-01
期刊：
影响因子：
3.5
通讯作者：
Kasahara, Y
中科院分区：
文献类型：
--
作者：
Harada, S;Yamamoto, T;Kasahara, Y
用岩浅大神经（GSP）记录了大鼠软腭对味觉刺激的综合反应，并与支配舌前部的鼓室索神经（CT）进行了比较。刺激包括不同浓度的NaCl、蔗糖、HCl和盐酸奎宁，以及0.5 M的6种糖。考察了阿米洛利对不同浓度NaCl、0.1 M乙酸钠、0.01 M糖精钠等钠盐的抑制作用。GSP中对糖的相位和张力反应均明显大于CT，而GSP中对NaCl的相位和张力反应均明显小于CT。虽然50 μ M浓度的阿米洛利显著抑制了CT对大范围NaCl的相位和张力反应，但在GSP中几乎没有抑制作用。当醋酸钠溶解在阿米洛利溶液中时，CT的强直反应下降到对照组的15%，GSP的轻微但显著下降到70%。CSP的这些反应特征可能在味觉信息的加工中起重要作用。
The integrated responses to gustatory stimuli applied to the soft palate were recorded from the greater superficial petrosal nerve (GSP) and were compared with those from the chorda tympani nerve (CT) innervating the anterior part of the tongue in the rat. Stimuli included various concentrations of NaCl, sucrose, HCl and quinine hydrochloride, and 0.5 M of six sugars. The inhibitory effects of amiloride on the responses to sodium salts, including various concentration of NaCl, 0.1 M sodium acetate and 0.01 M sodium saccharin, were also tested. Both the phasic and tonic responses to sugars in the GSP were significantly larger than those in the CT, whereas both responses to NaCl in the GSP were significantly smaller than those in the CT. Although amiloride at 50 mu M significantly depressed the phasic and tonic responses to NaCl with a wide range of concentration in the CT, little inhibitory effect was observed in the GSP. The tonic response to sodium acetate, when dissolved in amiloride solution, was depressed to 15% of the control in the CT, and slightly but significantly depressed to 70% in the GSP. These response characteristics of the CSP may play important roles in the processing of gustatory information.