Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma
Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma
复制标题
Beclin 1 依赖性细胞凋亡活性在肝细胞癌中的预后意义
DOI：
10.4161/auto.5.3.7658
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发表时间：
2009-04-01
期刊：
影响因子：
13.3
通讯作者：
Fan, Jia
中科院分区：
文献类型：
--
作者：
Shi, Ying-Hong;Ding, Zhen-Bin;Fan, Jia
自噬被认为在肿瘤发生和肿瘤进展中是重要的。然而，自噬在肝细胞癌（HCC）中的作用，特别是自噬蛋白的预后价值，尚未得到研究。我们的研究表明，肝癌细胞系在饥饿条件下自噬基因的基础表达及其相应的自噬活性降低，自噬缺陷与肝癌的高度恶性表型密切相关。此外，在对接受切除术的HCC患者进行的组织微阵列研究中，自噬相关蛋白Beclin 1在肿瘤中的表达极低，其中Beclin 1只能在Bcl-XL阳性表达背景下预测HCC患者的预后。基于我们的研究结果，我们提出，自噬缺陷，协同改变凋亡活性可能会促进肿瘤进展和肝癌预后不良，由于自噬可能与细胞凋亡在肝癌的调节相互作用的事实。
Autophagy is believed to be important in tumorigenesis and tumor progression. However, the role of autophagy in hepatocellular carcinoma (HCC), and especially the prognostic value of autophagic proteins, has not been investigated. Our studies described here show decreased basal expression of autophagic genes and their corresponding autophagic activity under conditions of starvation in HCC cell lines, and the autophagy defect correlated well with the highly malignant phenotype of HCC. In addition, in a tissue microarray study of HCC patients who underwent resection, the expression of the autophagy-related protein Beclin 1 was extremely low in tumors, where Beclin 1 could predict the prognosis of HCC patients only in a Bcl-XL-positive expression background. Based on our results, we propose that autophagy defects that synergize with altered apoptotic activity might facilitate tumor progression and poor prognosis of HCC, due to the fact that autophagy may interact with apoptosis in the regulation of HCC.