Evaluation of Total Tumor Volume and Pretransplantation α-Fetoprotein Level as Selection Criteria for Liver Transplantation in Patients With Hepatocellular Cancer
Evaluation of Total Tumor Volume and Pretransplantation α-Fetoprotein Level as Selection Criteria for Liver Transplantation in Patients With Hepatocellular Cancer
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DOI：
10.1016/j.transproceed.2012.12.010
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发表时间：
2013-06-01
影响因子：
0.9
通讯作者：
Krawczyk, M.
中科院分区：
文献类型：
--
作者：
Grat, M.;Kornasiewicz, O.;Krawczyk, M.
导论.适当选择肝细胞癌（HCC）患者进行肝移植对于最大限度地降低复发风险并提供与其他适应症相当的长期结局至关重要。在最近的一项大型研究中，提出了基于肿瘤总体积（TTV）和甲胎蛋白（AFP）浓度的选择标准。本研究的目的是评估肝移植治疗肝癌的结果在这些标准之内和之外。材料与方法。这项回顾性研究包括104例接受肝移植的HCC患者。评估了总生存率和肿瘤复发的风险因素。TTV <115 cm（3）（P = 0.021; HR 4.29; 95%CI，1.24-14.81）和AFP浓度>400 ng/mL（P = 0.002; HR 6.97; 95%CI，2.02-24.03）患者的总生存率和累积肿瘤复发率是复发的独立危险因素。TTV患者的3年复发率估计为4.2%
Introduction. Appropriate selection of hepatocellular cancer (HCC) patients for liver transplantation is crucial to minimize the risk of recurrence and provide long-term outcomes comparable with those for other indications. Selection criteria based on total tumor volume (TTV) and alpha-fetoprotein (AFP) concentrations were proposed in a recent large study. The aim of this study was to evaluate the results of liver transplantation for HCC within and beyond these criteria.Material and Methods. This retrospective study included 104 patients with HCC who underwent liver transplantation. Risk factors for overall survival and tumor recurrence were evaluated. Overall survival and cumulative tumor recurrence rate for patients with TTV 115 cm(3) (P = .021; HR 4.29; 95% CI, 1.24-14.81) and AFP concentration >400 ng/mL (P = .002; HR 6.97; 95% CI, 2.02-24.03) were independent risk factors for recurrence. The estimated 3-year tumor recurrence rate was 4.2% for patients with TTV