Fundus autofluorescence imaging in a patient with rapidly developing scotoma.
Fundus autofluorescence imaging in a patient with rapidly developing scotoma.
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DOI：
10.1097/icb.0b013e318260af5d
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Sparrow, Janet R
中科院分区：
文献类型：
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作者：
Gelman, Rony;Chen, Royce;Sparrow, Janet R
目得：评价急性黄斑神经性视网膜病变的情况下，涉及突然发展的暗点伴随着快速局灶性增加fundus autofluorescence.METHODS：患者的临床表现记录彩色眼底照片，眼底自发荧光，红外成像，高分辨率光谱域光学相干断层扫描。Humphrey视野10-2和MP-1微视野检查评估暗点。结果：视野缺损与眼底彩色照片和红外成像中可见的楔形病变在空间上一致。值得注意的是，病变在出现3周内获得的自体荧光图像上显示出强度增加。光学相干断层扫描显示光感受器内段/外段junctions在both eyes.CONCLUSION：这种情况下区分的相对快速性，病变成为高自发荧光眼底自发荧光图像。鉴于作为自体荧光来源的双类视黄酸在感光细胞中形成并继发性转移至视网膜色素上皮，自体荧光的快速增加不太可能仅反映视网膜色素上皮状态，而更可能指示感光细胞功能障碍和结构完整性丧失。
PURPOSE: To evaluate the findings in a case of acute macular neuroretinopathy involving sudden development of scotomas accompanied by rapid focal increases in fundus autofluorescence.METHODS: The clinical presentation of the patient was documented by color fundus photographs, fundus autofluorescence, infrared imaging, and high-resolution spectral domain optical coherence tomography. The scotomas were assessed by Humphrey visual field 10-2 and MP-1 microperimetry.RESULTS: Visual field defects exhibited spatial correspondence with wedge-shaped lesions demonstrable in color fundus photographs and infrared imaging. It was notable that the lesions exhibited increased intensity on autofluorescence images obtained within 3 weeks of presentation. Optical coherence tomography revealed focal loss of photoreceptor inner segment/outer segment junctions in both eyes.CONCLUSION: This case was distinguished by the relative rapidity with which the lesions became hyperautofluorescent in fundus autofluorescence images. Given that the bisretinoids that are the source of autofluorescence form in photoreceptor cells and are transferred to retinal pigment epithelium secondarily, the rapid increase in autofluorescence is unlikely to only reflect retinal pigment epithelium status and is more likely to be indicative of photoreceptor cell dysfunctioning and loss of structural integrity.