Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation.
Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation.
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DOI：
10.1155/2016/5954890
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发表时间：
2016
影响因子：
3.1
通讯作者：
Hwang SW
中科院分区：
文献类型：
--
作者：
Choi SI;Lim JY;Yoo S;Kim H;Hwang SW
TRPV1是一种已知的传感器离子通道，它将潜在的有害环境转换为伤害性初级传入神经末梢的电去极化。虽然TRPV1也在神经系统的中央区域表达，但其在该区域的作用仍不清楚。最近一系列关于脊髓突触的研究表明TRPV1在痛觉通路的突触传递中起重要作用。特别地，在病理性疼痛状态下，感觉神经元和中间神经元的中央末梢中的TRPV1被认为通常有助于疼痛加剧。这些观察结果可能会导致有关新的突触机制的见解，揭示脊髓TRPV1的隐蔽作用，并可能提供另一个机会，通过控制TRPV1调节病理性疼痛。在这篇综述中，我们介绍了这一观点的历史观点和最近有希望的结果的细节。我们还关注扩展问题和未解决的问题，以充分了解TRPV1在病理性疼痛中的作用。结合最近的研究结果，进一步深入分析TRPV1在中枢神经系统不同水平疼痛突触中的可塑性作用，将有助于更好地理解病理性疼痛机制，并有助于开发新的镇痛策略。
TRPV1 is well known as a sensor ion channel that transduces a potentially harmful environment into electrical depolarization of the peripheral terminal of the nociceptive primary afferents. Although TRPV1 is also expressed in central regions of the nervous system, its roles in the area remain unclear. A series of recent reports on the spinal cord synapses have provided evidence that TRPV1 plays an important role in synaptic transmission in the pain pathway. Particularly, in pathologic pain states, TRPV1 in the central terminal of sensory neurons and interneurons is suggested to commonly contribute to pain exacerbation. These observations may lead to insights regarding novel synaptic mechanisms revealing veiled roles of spinal cord TRPV1 and may offer another opportunity to modulate pathological pain by controlling TRPV1. In this review, we introduce historical perspectives of this view and details of the recent promising results. We also focus on extended issues and unsolved problems to fully understand the role of TRPV1 in pathological pain. Together with recent findings, further efforts for fine analysis of TRPV1's plastic roles in pain synapses at different levels in the central nervous system will promote a better understanding of pathologic pain mechanisms and assist in developing novel analgesic strategies.